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| http://dx.doi.org/10.1093/aje/kwt297 | DOI Listing |
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Employer Perspective on Pain Fellowship Education: A Survey to Understand the Current State of Pain Medicine Training.
J Pain Res
December 2024
Anesthesiology and Pain Department, Fondazione Istituto G. Giglio Cefalù, Palermo, Italy.
Background: Pain medicine care has expanded to encompass a wider range of conditions, necessitating updated education and training for pain specialists to utilize emerging technologies effectively. A national survey was conducted through several verified Pain organizations regarding pain physician employers' perspectives on pain medicine fellowship training and education. The survey aimed to gather insights from a diverse range of geographic locations, practice types (academic and private practice), and practice settings.
View Article and Find Full Text PDFA Narrative Review of the Role of Immunotherapy in Metastatic Carcinoma of the Colon Harboring a BRAF Mutation.
In Vivo
December 2024
Medical Oncology Unit, Policlinico, University of Palermo, Palermo, Italy.
Patients affected by metastatic carcinoma of the colon/rectum (mCRC) harboring mutations in the BRAF gene (MBRAF) respond poorly to conventional therapy and have a prognosis worse than that of patients without mutations. Despite the promising outcomes of targeted therapy utilizing multi-targeted inhibition of the mitogen-activated protein kinase (MAPK) signaling system, the therapeutic efficacy, especially for the microsatellite stable/DNA proficient mismatch repair (MSS/PMMR) subtype, remains inadequate. Patients with MBRAF/mCRC and high microsatellite instability or DNA deficient mismatch repair (MSI-H/DMMR) exhibit a substantial tumor mutation burden, suggesting a high probability of response to immunotherapy.
View Article and Find Full Text PDFMeasuring habituation to stimuli: The Italian version of the Sensory Habituation Questionnaire.
PLoS One
December 2024
Department of Psychology, Educational Sciences and Human Movement, University of Palermo, Palermo, Italy.
Sensory habituation allows us to decrease responsiveness to repetitive or prolonged stimuli over time, making them easy to filter out and not interfere with ongoing activities. As such, habituation could be an important aspect to be evaluated within a sensory and cognitive assessment. The main aim of the present study was to validate an Italian version of the Sensory Habituation Questionnaire (S-Hab-Q), a self-report tool assessing how long an adult individual takes to adapt to daily sensory stimuli.
View Article and Find Full Text PDFDifferent thermal regimes and susceptibility to herbivory do not constrain seagrass seedling restoration.
Mar Environ Res
December 2024
University of Sassari, Department of Chemical, Physical, Mathematical and Natural Sciences, Sassari, Italy; National Biodiversity Future Centre, Palermo, Italy.
Recovering seagrass ecosystems through restoration has become impellent to re-establish their functionality and services. Although the use of seedlings may represent an appropriate solution, little information is provided on the seedling-based restoration effectiveness with influence of biotic and abiotic interactions. Survival, morphological development and leaf total phenol content of transplanted Posidonia oceanica seedlings were evaluated under different origin, thermal regimes and herbivore pressure through a five-months field experiment in two MPAs, located on the west (cold) and east (warm) Sardinia coast to explore the effectiveness of seedling-based restoration.
View Article and Find Full Text PDFBrexucabtagene autoleucel in-vivo expansion and BTKi refractoriness have a negative influence on progression-free survival in mantle cell lymphoma: Results from CART-SIE study.
Br J Haematol
December 2024
Hematology, School of Medicine, Università degli Studi di Milano, Milan, Italy.
Brexucabtagene autoleucel (brexu-cel) has revolutionized the treatment of patients affected by mantle cell lymphomas. In this prospective, observational multicentre study, we evaluated 106 patients, with longitudinal brexu-cel kinetics in peripheral blood monitored in 61 of them. Clinical outcomes and toxicities are consistent with previous real-world evidence studies.
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