The structure of a novel indigoid component was characterized by X-ray crystallography. This compound exhibited excellent anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv in whole cell culture showing a submicromolar minimum inhibitory concentration (MIC). A synthesis of this molecule was designed and carried out to produce sufficient material for further testing. The in vitro profile, structure, and first synthesis of this indigoid component is reported.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922930 | PMC |
| http://dx.doi.org/10.1016/j.bmcl.2013.11.024 | DOI Listing |
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