The objective of this study was to determine whether breath alcohol elimination rate varies as a function of age, gender, and drinking practice, factorially combined. Eighty-four men and 84 women drank enough alcohol to produce peak BrACs of .110 g/210 L for heavy and moderate drinkers and BrACs of .090 g/210 L for light drinkers. An Intoxilyzer 5000 was used to generate the concentration-time profiles. Mean (M) elimination rates (g/210 L/h) were found to be higher for women (N=84, M=.0182, SD=.0033) than for men (N=84, M=.0149, SD=.0029), F(1, 144)=57.292, p<.001; higher for heavy drinkers (N=56, M=.0176, SD=.0038) than for light and moderate drinkers combined (N=112, M=.0160, SD=.0032), F(1, 144)=12.434, p<.01; and higher for older subjects (51-69 years, N=42, M=.0180, SD=.0038) than younger subjects (19-50 years, N=126, M=.0161, SD=.0033), F(1, 144)=14.324, p<.001. None of the two-way interactions (age × gender, age × drinking practice, gender × drinking practice) or the three-way interaction (age × gender × drinking practice) was statistically significant. Limitations of the current study and suggestions for further research are discussed.
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http://dx.doi.org/10.1016/j.forsciint.2013.09.017 | DOI Listing |
ACS Sens
January 2025
Interdisciplinary Research Division Smart HealthCare, Indian Institute of Technology Jodhpur, Jodhpur 342030, India.
Electronic nose (e-nose) systems are well known in breath analysis because they combine breath printing with advanced and intelligent machine learning (ML) algorithms. This work demonstrates development of an e-nose system comprising gas sensors exposed to six different volatile organic compounds (VOCs). The change in the voltage of the sensors was recorded and analyzed through ML algorithms to achieve selectivity and predict the VOCs.
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January 2025
Dep. Oral Biochemistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, 1081, LA, The Netherlands.
The increasing use of recreational nitrous oxide ([Formula: see text]O) in the Netherlands and its link to traffic accidents highlights the need for reliable detection methods for law enforcement. This study focused on ex vivo detection of [Formula: see text]O in exhaled breath and examining its persistence in the human body. Firstly, a low-cost portable infrared based detector was selected and validated to detect [Formula: see text]O in air.
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October 2024
Veterans Affairs Boston Healthcare System, West Roxbury, Massachusetts.
: A 65-year-old male veteran presented to the Veterans Affairs Boston Healthcare System (VABHS) emergency department with progressive fatigue, dyspnea on exertion, lightheadedness, and falls over the last month. New bilateral lower extremity numbness up to his knees developed in the week prior to admission and prompted him to seek care. Additional history included 2 episodes of transient loss of consciousness resulting in falls and a week of diarrhea, which had resolved.
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January 2025
Division of Anesthesia Critical care, Emergency and Pain Medicine, University Hospital Centre Nimes, Nimes, Occitanie, France.
Introduction: Intensive care unit (ICU) patients under mechanical ventilation experience mild-to-severe pain. International guidelines emphasise the importance and benefits of multimodal analgesia to minimise opioid consumption and its side effects. However, no recommendation about drugs or protocol has been formulated.
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January 2025
Institute for Breath Research, University of Innsbruck, Innrain 80/82, Innsbruck, 6020, Austria.
Cytochrome P450 (CYP) 3A4 plays a major role in drug metabolism. Its activity could be determined by non-invasive and cost-effective assays, such as breath analysis, for the personalised monitoring of drug response. For the first time, we identify an isotopically unlabelled CYP3A4 substrate, tolterodine that leads to the formation of a non-toxic volatile metabolite, acetone, which could potentially be applied to monitor CYP3A4 activity in humans.
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