Crotalus durissus are found from Mexico to northern Argentina in a highly disjunct distribution. According to some studies, this species is prone to occupy areas disturbed by human activities and floods comprise a plausible method of dispersal as inferred for some North American rattlesnakes. Based on the literature, it seems plausible that Crotalus durissus expanded their natural distribution in Brazil due to floods, but only in a few municipalities in Rio de Janeiro State. Data entries of Butantan Institute, in São Paulo, Brazil, from 1998 to 2012 show a declining tendency of snakes brought by donors. In addition, research shows no evidence of Crotalus durissus being an expanding species in the Brazilian territory.
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http://dx.doi.org/10.1186/1678-9199-19-30 | DOI Listing |
Toxicon
December 2024
Teaching and Research Center, Francisca Mendes Heart Hospital Foundation, Manaus, 69097-720, Brazil; Research management, Hospital Foundation of Hematology and Hemotherapy of Amazonas, 69050-001, Brazil. Electronic address:
We evaluated the efficacy of freeze-dried Bothrops-Lachesis-Crotalus antivenom and liquid Crotalus antivenoms to neutralize Crotalus durissus ruruima (Cdr) venom (Roraima, Brazil) comparing with C. d. terrificus (Cdt) venom.
View Article and Find Full Text PDFCurr Protein Pept Sci
November 2024
Laboratório de Imunologia Celular Aplicada à Saúde, Fundação Oswaldo Cruz, FIOCRUZ Rondônia, Porto Velho-RO, Brazil.
Background: Crotalus Neutralizing Factor (CNF) is a γ-type Phospholipase A2 (PLA2) inhibitor present in the blood of Crotalus durissus terrificus snake. Particularly, CNF inhibits the toxic action of Crotoxin (CTX), which is a major neurotoxin found in C. d.
View Article and Find Full Text PDFRev Soc Bras Med Trop
October 2024
Universidade Federal do Ceará, Hospital Universitário Walter Cantídio, Fortaleza, CE, Brasil.
Toxicon X
December 2024
Tecnologico de Monterrey, Institute for Obesity Research, Ave. Eugenio Garza Sada Sur 2501, C.P. 64849, Monterrey, N.L., Mexico.
Animal venoms are natural products that have served as a source of novel molecules that have inspired novel drugs for several diseases, including for metabolic diseases such as type-2 diabetes and obesity. From venoms, toxins such as exendin-4 () and crotamine () have demonstrated their potential as treatments for obesity. Moreover, other toxins such as Phospholipases A and Disintegrins have shown their potential to modulate insulin secretion in vitro.
View Article and Find Full Text PDFActa Neuropsychiatr
October 2024
Laboratory of Neuroanatomy & Neuropsychobiology, Department of Pharmacology, School of Medicine of Ribeirão Preto of the University of São Paulo (FMRP-USP), Ribeirão Preto, São Paulo, Brazil.
The dorsal midbrain comprises dorsal columns of the periaqueductal grey matter and corpora quadrigemina. These structures are rich in beta-endorphinergic and leu-enkephalinergic neurons and receive GABAergic inputs from substantia nigra pars reticulata. Although the inferior colliculus (IC) is mainly involved in the acoustic pathways, the electrical and chemical stimulation of central and pericentral nuclei of the IC elicits a vigorous defensive behaviour.
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