Background: Postural screening remains a powerful tool that can be used to identify children and adolescents with scoliosis or sagittal plane deformities. The aim of this study was to assess the time effectiveness of implemented telediagnostic screening procedures.
Materials And Methods: Medical images (virtual objects) of acquired clouds of points of 100 subjects of both sexes were chosen at random from the database and used for parametric evaluation for this study. This study was performed using a newly developed three-dimensional (3D) back surface topography measurement system for posture and scoliosis using a structured light method. The duration of each step of therapist/nurse/physician-assisted 3D assessment was measured independently with a stopwatch. Two configurations of PC computers and Internet connections were used to test the time effectiveness. Scoliotic postures were detected using cutoff values of angle of trunk rotation, Posterior Trunk Symmetry Index, and Deformity in the Axial Plane Index indices.
Results: The overall assessment of all subjects consumed from 2 h 55 min 55 s to 3 h 18 min 59 s dependent on PC and Internet connection configuration. Average examination time per subject ranged from 2 min 43 s to 4 min 51 s, respectively. The virtual landmarking and report generation times were dependent on the PC configuration (p<0.001). Our study confirmed satisfactory time effectiveness of the implemented telediagnostic postural screening procedure. We assume that it may influence the cost-effectiveness of the screening, which is usually mentioned as an important factor for recommendations against postural school screening. Relatively fast Internet connection and a medium-level PC configuration are sufficient for achieving a reasonably short time of 3D posture assessment of a virtual object representing a real subject's back surface.
Conclusions: The efficiency of remote assessment of exact 3D surface topography can be used in large-scale studies for posture and scoliosis epidemiology.
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http://dx.doi.org/10.1089/tmj.2013.0107 | DOI Listing |
Muscle Nerve
January 2025
Department of Neurology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, New York, USA.
Introduction/aims: Neonatal Fc receptor (FcRn) inhibitors represent a promising treatment option for patients with generalized myasthenia gravis (gMG); however, data on clinical use are limited. The aim of this report is to describe one center's approach to efgartigimod dosing in patients with gMG.
Methods: Medical records of patients with acetylcholine receptor antibody-positive (AChR-Ab+) gMG whose symptoms were not adequately controlled by oral medications and/or intravenous immunoglobulin who received efgartigimod between January 2022 and January 2024 were retrospectively evaluated.
Dis Model Mech
January 2025
Institute of Molecular Health Sciences, Department of Biology, ETH Zürich, 8093 Zürich, Switzerland.
Atopic dermatitis (AD) is a chronic inflammatory skin disease, characterized by an impaired epidermal barrier and immunological alterations. The activity of the cytoprotective NRF2 transcription factor is reduced in the epidermis of AD patients. To determine the functional relevance of this deficiency, we used mice lacking fibroblast growth factor receptors 1 and 2 in keratinocytes (K5-R1/R2 mice), which exhibit several AD-like symptoms.
View Article and Find Full Text PDFOrg Biomol Chem
January 2025
School of Life Sciences and Health Engineering, Jiangnan University, Jiangsu, 214122, China.
Dysfunction in the SHP1 enzyme can cause cancers and many diseases, so it is of great significance to develop novel small molecule SHP1 inhibitors. Through continuous monitoring of metabolic and targeted processes of SHP1 inhibitors in real-time, we can evaluate the effectiveness and toxicity of the inhibitors, further optimize drug design, and explore SHP1 biology. Indoloquinoxaline is an important class of N-containing heterocycle, which has been studied and applied in the pharmacological field and in optoelectronic materials.
View Article and Find Full Text PDFStroke
January 2025
Department of Neurology, National Center for Neurological Disorders, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China (X.C., L.H., Y.L., Yiran Zhang, X.L., S.L., L.Y., Q.D.).
Background: Whether it is effective and safe to extend the time window of intravenous thrombolysis up to 24 hours after the last known well is unknown. We aimed to determine the efficacy and safety of tenecteplase in Chinese patients with acute ischemic stroke due to large/medium vessel occlusion within an extended time window.
Methods: Patients with ischemic stroke presenting 4.
J Anim Physiol Anim Nutr (Berl)
January 2025
Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Roughage can be a significant source of vitamin D in herbivore diets. The vitamin D content of forages can vary considerably and depends, among others, on plant species, plant maturity and climate fluctuations. Ultraviolet B (UVB) exposure causes conversion of provitamin D to vitamin D and thus represents the most important influence.
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