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Transplant-Free Approach in Relapsed Hodgkin Lymphoma in Children, Adolescents, and Young Adults: A Nonrandomized Clinical Trial.
JAMA Oncol
January 2025
Children's Wisconsin, Milwaukee.
Importance: Retrieval strategies for children, adolescents, and young adults with relapsed classic Hodgkin lymphoma (cHL) aim to maintain efficacy while minimizing long-term toxic effects. Children, adolescents, and young adults with low-risk, relapsed cHL may benefit from replacing high-dose chemotherapy and autologous stem cell transplant with less intensive involved-site radiotherapy (ISRT).
Objective: To evaluate a risk-stratified, response-adapted, transplant-free approach for treatment of children, adolescents, and young adults with low-risk relapsed cHL with nivolumab plus brentuximab vedotin (BV) followed by BV plus bendamustine for patients with suboptimal response and ISRT (30.
Personalized multifactorial risk assessment in neoadjuvant-treated breast carcinoma.
Breast Cancer Res Treat
December 2024
Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10/MedD5A, 20500, Turku, Finland.
Article Synopsis
- The study aims to improve predictions of disease outcomes for breast cancer patients undergoing neoadjuvant treatment (NAT) by analyzing clinical and histopathological data.
- Researchers evaluated a cohort of 257 Finnish breast cancer patients over 13 years, identifying significant prognostic factors and previously overlooked histological features that correlate with treatment response and survival.
- The findings suggest the importance of re-assessing biomarkers post-treatment and developing personalized surveillance and treatment strategies based on comprehensive evaluations of patient data and risk factors.
PSA testing in primary care: is it time to change our practice?
BMC Prim Care
December 2024
Department of Urology, Erasmus Cancer Institute, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Background: Historical prostate-specific antigen (PSA)-based screening studies reduced prostate cancer-related deaths but also led to overdiagnosis/overtreatment. Since then, opportunistic PSA testing has increased, and late-stage diagnoses and prostate-cancer related deaths are rising.
Objectives: To review current trends regarding PSA testing in primary care and propose a collaborative approach to improve early prostate cancer detection.
Role of Radiotherapy in the Management of Elderly Patients With Lymphoma.
Semin Radiat Oncol
January 2025
Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers University, NJ.. Electronic address:
Lymphoma in elderly patients has unique treatment challenges due to baseline co-morbidities, nutrition status, impairment in functional capacities and fitness. While geriatric-specific assessment can be used to tailor treatment decisions, lack of adequate representation of elderly patients in lymphoma clinical trials impairs generalizability. Radiation treatment has traditionally been associated with high response and local control for lymphomas.
View Article and Find Full Text PDFEvolving Strategies in the Management of Transplant-Eligible Patients with Newly Diagnosed Multiple Myeloma.
Presse Med
December 2024
Service d'Hematologie, CHU de Toulouse - IUCT Oncopole, Université UPS Toulouse 3, Toulouse, France. Electronic address:
Multiple myeloma treatment has evolved significantly with the introduction of triplet and quadruplet regimens, notably incorporating anti-CD38 antibodies. While autologous stem cell transplantation remains a cornerstone of therapy, its role in the context of increasingly effective upfront treatments is debated. Current guidelines still recommend transplant for all eligible patients, especially those with high-risk features at diagnosis, despite concerns regarding the lack of overall survival benefits and the potential long-term toxicities associated with high-dose melphalan.
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