A radical [3 + 2]-divinylcyclopropane annulation cascade has been extended to encompass five D-ring variants of the meloscine/epimeloscine core structure. Representative ABCD tetracyclic intermediates were further elaborated with novel substituted E-rings through subsequent transformations of advanced intermediates that provided opportunities for late-stage variation of the B-ring (lactam) N-substituents which were also developed.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910537 | PMC |
http://dx.doi.org/10.1021/ol403078e | DOI Listing |
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