Purpose: The objective of the present study was to evaluate the protective effect of methanol extract of Prosopis cineraria (MPC) against N-nitrosodiethylamine (DEN, 200mg/kg) induced Phenobarbital promoted experimental liver tumors in male Wistar rats.
Methods: The rats were divided into four groups, each group consisting of six animals. Group 1 served as control animals. Liver tumor was induced in group 2, 3, and 4 and Group 3 animals received MPC 200mg/kg and Group 4 animals received MPC 400mg/kg.
Results: Administration of DEN has brought down the levels of membrane bound enzymes like Na(+)/ K(+) ATPase, Mg(2+) ATPase and Ca(2+)ATPase which were later found to be increased by the administration of Prosopis cineraria (200 and 400mg/kg) in dose dependent manner. The MPC extract also suppressed the levels of glycoproteins like Hexose, Hexosamine and Sialic acid when compared to liver tumor bearing animals.
Conclusion: Our study suggests that MPC may extend its protective role by modulating the levels of membrane bound enzymes and suppressing glycoprotein levels.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845991 | PMC |
| http://dx.doi.org/10.5681/apb.2012.027 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Leveraging molecular dynamics, physicochemical, and structural analysis to explore OMP33-36 protein as a drug target in Acinetobacter baumannii: An approach against nosocomial infection.
J Mol Graph Model
January 2025
Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow Campus, Gomtinagar Extension, Lucknow, 226028, India; Research Cell, Amity University Uttar Pradesh, Lucknow Campus, India. Electronic address:
The Acinetobacter baumannii is a member of the "ESKAPE" bacteria responsible for many serious multidrug-resistant (MDR) illnesses. This bacteria swiftly adapts to environmental cues leading to the emergence of multidrug-resistant variants, particularly in hospital/medical settings. In this work, we have demonstrated the outer membrane protein 33-36 (Omp33-36) porin as a potential therapeutic target in A.
View Article and Find Full Text PDFPotential Antioxidant Effects of Common Omani Ethnobotanical Plants.
Prev Nutr Food Sci
December 2024
Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat 123, Oman.
Phytonutrients (e.g., phenolic compounds and flavonoids) are secondary plant metabolites that play an important role in the defense against pathogens and protection from oxidative injury because of their potential ability to neutralize reactive oxygen species.
View Article and Find Full Text PDFEmergence of an unconventional Enterobacter cloacae-derived Iturin A C-15 as a potential therapeutic agent against methicillin-resistant Staphylococcus aureus.
Arch Microbiol
December 2024
Centre for Research and Development of Scientific Instruments (CRDSI), Indian Institute of Technology, Jodhpur, Rajasthan, 342030, India.
Antimicrobial resistance poses a significant global health threat by reducing the effectiveness of conventional antibiotics, particularly against pathogens like Methicillin-resistant Staphylococcus aureus (MRSA). This study investigates the antimicrobial potential of rhizospheric soil bacteria from Prosopis cineraria (Sangri) in the Thar Desert. Bacterial strains isolated from these samples were observed to produce secondary metabolites, notably, Iturin A C-15 cyclic lipopeptide (SS1-3-P) which was extracted from strain Enterobacter cloacae SS1-3 and was purified and characterized using reverse-phase HPLC, ESI-LC/MS, Nile-Red Assay, and FT-IR analysis.
View Article and Find Full Text PDFMicrobiome properties in the root nodules of a leguminous desert tree.
Microbiol Spectr
June 2024
Khalifa Center for Genetic Engineering and Biotechnology, United Arab Emirates University, Al-Ain, UAE.
We conducted a comprehensive analysis of the total microbiome and transcriptionally active microbiome communities in the roots and root nodules of , an important leguminous tree in arid regions of many Asian countries. Mature trees growing in the desert did not exhibit any detected root nodules. However, we observed root nodules on the roots of growing on a desert farm and on young plants growing in a growth chamber, when inoculated with rhizosphere soil, including with rhizosphere soil from near desert tree roots that had no nodules.
View Article and Find Full Text PDFIncorporation of Extract Improved the Mechanical, Barrier and Antioxidant Properties but Not the Antibacterial Activity of Fish Scale Gelatin Film.
Foods
February 2024
Fish Processing Technology Division, Faculty of Marine Sciences, Chabahar Maritime University, Chabahar 99717-78631, Iran.
Scale gelatin films derived from croaker fish and infused with () extract (PE) at concentrations of 0.3% and 0.7% were produced.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!