The objective of the present study was to investigate the anticancer activity of Chinese medicine Caulis Spatholobi extract on multicentric osteosarcoma cells. Ultraviolet spectrophotometry was used to determine the total flavonoid content in each sample; vanillin sulphuric acid assay was used to determine the condensed tannin content in each sample; and the varying degrees of inhibitory activities of ethanol, ethyl acetate and n-butanol extracts of Caulis Spatholobi on human osteosarcoma Saos-2 cells were studied. The results showed that the inhibitory activity of ethyl acetate extract was the highest among the four extracts. The condensed tannin contents of 1.2 mg/mL Caulis Spatholobi water extract, ethanol extract, ethyl acetate extract and petroleum ether extract were 26.23%, 48.36%, 70.18% and 40.51% respectively; and condensed tannin content of 1.5 mg/mL Caulis Spatholobi water extract, ethanol extract, ethyl acetate extract and petroleum ether extract were 4.15%, 5.81%, 8.76% and 7.30% respectively.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847413 | PMC |
| http://dx.doi.org/10.4314/ajtcam.v10i5.6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Self-healing hydrogels loaded with Spatholobi Caulis alleviate disc degeneration by promoting autophagy in nucelus pulposus.
Mater Today Bio
December 2024
Department of Orthopedics, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Article Synopsis
- Intervertebral disc degeneration (IDD) significantly affects human health and is linked to apoptosis and senescence, but autophagy can help combat these issues.
- The study found that Spatholobi caulis (SC), an herbal remedy, can enhance autophagy and reduce cell death in Nucleus pulposus cells; however, its absorption in animal studies was poor.
- To improve its effectiveness, researchers developed a hydrogel combining quaternary ammonium chitosan (QCS) and oxidized starch (OST), which showed promise in enhancing cell viability, promoting tissue repair, and reducing disc degeneration in rats when administered via microneedles.
First Report in China of Leaf Blight on Dunn Caused by .
Plant Dis
November 2024
Guangxi Botanical Garden of Medicinal Plants, Guangxi Key Laboratory of for High Quality Formation and Utilization of Dao-Di Herbs, Nanning, China;
Article Synopsis
- Spatholobus suberectus Dunn is a key medicinal plant in China, recognized as the sole source for the herbal medicine Spatholobi caulis in the China Pharmacopeia.
- In November 2023, a leaf disease affected 80% of plants in a plantation in Nanning, characterized by necrotic leaf tips with gray discoloration and brown margins.
- Researchers isolated 36 fungal pathogens from the symptomatic leaves, identifying one specific isolate, YY-3-S, with morphological traits of Diaporthe sp, followed by genetic sequencing for further identification.
[Effect of Spatholobi Caulis extract from ethyl acetate on immune killing function of NK cells].
Zhongguo Zhong Yao Za Zhi
March 2024
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
This study aims to investigate the regulatory effect of the Spatholobi Caulis extract from ethyl acetate(SEA) on natural killer(NK) cells under physiological conditions and elucidate the underlying mechanism. The C57BL/6 mice were randomized into NC and SEA groups, and NK-92 cells were respectively treated with 0, 25, 50, and 100 μg·mL~(-1) SEA. The body weight and immune organ index of the mice were compared between groups.
View Article and Find Full Text PDFEthyl-acetate extract of Spatholobi Caulis blocked the pro-metastatic support from the hemato-microenvironment of colon cancer by specific disruption of tumor-platelet adhesion.
Phytomedicine
June 2024
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, State key laboratory for quality ensurance and sustainable use of Dao-di herbs, Beijing 100700, China. Electronic address:
Background: Within the pro-metastatic hemato-microenvironment, interaction between platelets and tumor cells provides essential support for tumor cells by inducing Epithelial-Mesenchymal Transition (EMT), which greatly increases the stemness of colon cancer cells. Pharmacologically, although platelet deactivation has proved to be benefit against metastasis, its wide application is severely restricted due to the bleeding risk. Spatholobi Caulis, a traditional Chinese herb with circulatory promotion and blood stasis removal activity, has been proved to be clinically effective in malignant medication, leaving its mechanistic relevance to tumor-platelet interaction largely unknown.
View Article and Find Full Text PDFMolecular mechanism of Spatholobi Caulis treatment for cholangiocarcinoma based on network pharmacology, molecular docking, and molecular dynamics simulation.
Naunyn Schmiedebergs Arch Pharmacol
August 2024
Department of Hepatobiliary Surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, No. 61 Jiefang West Road, Changsha, 410005, Hunan, People's Republic of China.
Cholangiocarcinoma (CCA) is a type of malignant tumor originating from the intrahepatic, periportal, or distal biliary system. The treatment means for CCA is limited, and its prognosis is poor. Spatholobi Caulis (SC) is reported to have effects on anti-inflammatory and anti-tumor, but its role in CCA is unclear.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!