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| http://dx.doi.org/10.1161/CIRCRESAHA.113.302749 | DOI Listing |
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Safety, Tolerability and Pharmacokinetic-Pharmacodynamic Relationship of NX210c Peptide in Healthy Elderly Volunteers: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascending Dose Study.
Neurol Ther
December 2024
Axoltis Pharma, Bioparc Laennec, 60 Avenue Rockefeller, 69008, Lyon, France.
Introduction: Blood-brain barrier (BBB) integrity is fundamental to brain homeostasis, enabling control of substance exchange and safeguarding neurons against harmful toxins, pathogens, and immune cells that lead to dysregulation and inflammation involved in ageing and neurodegenerative diseases (NDD). The cyclized peptide NX210c is a thrombospondin type 1 repeat analogue derived from subcommissural organ-spondin. It exerts beneficial effects in animal models of NDD owing to its effects on neurons and endothelial cells.
View Article and Find Full Text PDFExploring biomarkers for diagnosing and predicting organ dysfunction in patients with perioperative sepsis: a preliminary investigation.
Perioper Med (Lond)
July 2024
Department of Anaesthesiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Article Synopsis
- The study focuses on identifying new biomarkers for early diagnosis and prediction of organ dysfunction in septic patients undergoing emergency surgery.
- Through various analyses, researchers identified 146 differentially expressed proteins (DEPs) in sepsis patients, with six proteins, including Cathepsin B and S100-A9, showing significant increases compared to controls.
- Logistic regression analysis indicated that these biomarkers could help predict organ dysfunction, particularly renal failure, with a strong model performance evidenced by a C-index of 0.898.
Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review of Observational Studies.
Curr Pain Headache Rep
July 2024
Unit of Immunonutrition and Clinical Nutrition, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, Larissa, Greece.
Purpose Of Review: Fibromyalgia syndrome (FMS) is a disease of unknown pathophysiology, with the diagnosis being based on a set of clinical criteria. Proteomic analysis can provide significant biological information for the pathophysiology of the disease but may also reveal biomarkers for diagnosis or therapeutic targets. The present systematic review aims to synthesize the evidence regarding the proteome of adult patients with FMS using data from observational studies.
View Article and Find Full Text PDFThrombospondin 1 enhances systemic inflammation and disease severity in acute-on-chronic liver failure.
BMC Med
March 2024
Precision Medicine Center, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, 318000, China.
Background: The key role of thrombospondin 1 (THBS1) in the pathogenesis of acute-on-chronic liver failure (ACLF) is unclear. Here, we present a transcriptome approach to evaluate THBS1 as a potential biomarker in ACLF disease pathogenesis.
Methods: Biobanked peripheral blood mononuclear cells (PBMCs) from 330 subjects with hepatitis B virus (HBV)-related etiologies, including HBV-ACLF, liver cirrhosis (LC), and chronic hepatitis B (CHB), and normal controls (NC) randomly selected from the Chinese Group on the Study of Severe Hepatitis B (COSSH) prospective multicenter cohort underwent transcriptome analyses (ACLF = 20; LC = 10; CHB = 10; NC = 15); the findings were externally validated in participants from COSSH cohort, an ACLF rat model and hepatocyte-specific THBS1 knockout mice.
Diagnosis and Prognosis of Thyroid Cancer by Immune-related Genes.
Am J Clin Oncol
January 2024
Department of Thyroid and Breast Surgery, Jingmen N0.2 People's Hospital, Jingmen, China.
Background: Thyroid carcinoma (THCA) is the most common malignant endocrine tumor with low mortality and a relatively good prognosis. Immune genes have attracted much attention as molecular markers of THCA prognosis and potential targets of immunotherapy.
Methods: Our study analyzed the transcriptome and clinical data of immune-related genes (IRGs) of THCA in gene expression omnibus, the cancer genome atlas-THCA, and ImmPort databases.
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