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Protective effect of total flavonoids extracted from the leaves of Murraya paniculata (L.) Jack on diabetic nephropathy in rats. | LitMetric

Protective effect of total flavonoids extracted from the leaves of Murraya paniculata (L.) Jack on diabetic nephropathy in rats.

Food Chem Toxicol

Department of Pharmacology, School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. Electronic address:

Published: February 2014

AI Article Synopsis

  • The study investigates the effects of total flavonoids from Murraya paniculata leaves (TFMP) on diabetic nephropathy in rats induced by a high-fat diet and streptozotocin.
  • Over 13 weeks, TFMP treatment significantly improved renal function and reduced various harmful markers, such as blood urea nitrogen and creatinine levels.
  • Additionally, TFMP enhanced antioxidant levels and mitigated kidney damage related to diabetes, suggesting it has protective effects against renal issues in diabetic conditions.

Article Abstract

This study was designed to evaluate the effects of total flavonoids extracted from the leaves of Murraya paniculata (L.) Jack (TFMP) on diabetic nephropathy. High fat diet and streptozotocin-induced diabetic rats were treated with the TFMP (35 or 70 mg/kg) for 13 weeks. Changes of renal function parameters were examined at the end of administration. Some kidneys were collected for histological and immunohistochemistry studies, the other ones for biochemical parameters analysis. TFMP significantly decreased the levels of serum blood urea nitrogen, serum creatinine, creatinine clearance, interleukin-6, urinary albumin, 24h-urinary albumin excretion rate, kidney weight to body weight ratio and fasting blood glucose in diabetic rats. Meanwhile, the levels of triglycerides, total and LDL cholesterols in the TFMP treated diabetic rats were lower and the high-density lipoprotein cholesterol level was higher than that in the diabetic rats. TFMP treatment significantly blocked the decrease of superoxide dismutase and glutathione peroxidase and increase of malondialdehyde levels in diabetic rats. Furthermore, the TFMP not only decreased the expression of TGF-β1 and CTGF protein, but also reduced diabetes-induced morphological alterations of the kidney. These results suggest that TFMP is a protective agent against renal damage in diabetic nephropathy.

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Source
http://dx.doi.org/10.1016/j.fct.2013.11.043DOI Listing

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