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Extensive methylation analysis of circulating tumor DNA in plasma of patients with gastric cancer.
Sci Rep
December 2024
Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamada-Oka, Suita City, Osaka, 565-0871, Japan.
DNA methylation is known to be involved in tumor progression. This is the first study to perform an extensive methylation analysis of plasma circulating tumor DNA (ctDNA) using targeted bisulfite sequencing in gastric cancer (GC) patients to evaluate the usefulness of ctDNA methylation as a new biomarker. Sixteen patients who received chemotherapy for recurrent GC were included.
View Article and Find Full Text PDFDetection of a novel DNA methylation marker panel for esophageal cancer diagnosis using circulating tumor DNA.
BMC Cancer
December 2024
Department of Molecular Pathology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, No 127, Dongming Road, Zhengzhou, 450008, Henan, China.
Background: Esophageal cancer (ECa) is one of the most deadly cancers, with increasing incidence worldwide and poor prognosis. While endoscopy is recommended for the detection of ECa in high-risk individuals, it is not suitable for large-scale screening due to its invasiveness and inconvenience.
Methods: In this study, a novel gene methylation panel was developed for a blood-based test, and its diagnostic efficacy was evaluated using a cohort of 304 participants (203 cases, 101 controls).
TFPI2 hypermethylation promotes diabetic atherosclerosis progression through the Ap2α/PPARγ axis.
J Mol Cell Cardiol
December 2024
Department of Cardiology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao 266003, Shandong, China. Electronic address:
Article Synopsis
- - Diabetes significantly increases the risk of atherosclerosis, causing serious cardiovascular problems, with research showing that the protein TFPI2 is expressed at lower levels in atherosclerotic plaques of diabetic patients.
- - Experiments demonstrated that knocking down TFPI2 in non-diabetic mice led to more severe plaque buildup and increased inflammation, while boosting TFPI2 in diabetic mice improved plaque stability and promoted beneficial M2 macrophage activity.
- - The study reveals that the interaction between TFPI2 and a transcription factor called AP-2α is essential for regulating inflammation and plaque stability in diabetes, suggesting that targeting this pathway could be a novel way to treat diabetes-related cardiovascular diseases.
Identification of new subtypes of breast cancer based on vasculogenic mimicry related genes and a new model for predicting the prognosis of breast cancer.
Heliyon
September 2024
Cancer Center, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, 710061, China.
Article Synopsis
- Breast cancer is a serious health threat for women and the presence of vasculogenic mimicry (VM) is linked to poorer outcomes in patients.
- The study used various databases to explore the role of VM-related genes in breast cancer, analyzing aspects like gene expression, mutation status, and immune cell infiltration.
- By clustering patients based on VM characteristics, the research identified two groups, where one group with greater immune activity showed better survival rates, and three important prognostic genes were highlighted for future treatment strategies.
Tissue factor pathway inhibitor-2 (TFPI-2)-an underappreciated partaker in cancer and metastasis.
Cancer Metastasis Rev
December 2024
Department of Pathology-School of Medicine, Bioactive Lipids Research Program, Wayne State University, 540 East Canfield Avenue, Detroit, MI, 48201, USA.
The coagulation system is known to play an important role in cancer development and metastasis, but the precise mechanisms by which it does so remain incompletely understood. With this in mind, we provide an updated overview of the effects of TFPI-2, a protease inhibitor, on cancer development and metastasis. TFPI-2 interacts with the thrombin cascade and also employs other mechanisms to suppress cancer growth and dissemination, which include extracellular matrix stabilization, promotion of caspase-mediated cell apoptosis, inhibition of angiogenesis and transduction of intracellular signals.
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