AI Article Synopsis
- The study aimed to clarify inconsistent findings regarding the relationship between the amplitude of the first heart sound (S1) and the rising rate of left ventricular pressure (LVP) by conducting experiments on anesthetized dogs while varying hemodynamic conditions.
- Researchers simultaneously collected data from phonocardiograms, electrocardiograms, and intracardiac pressure to analyze how S1 amplitude correlates with the rate of LVP change through various mathematical models.
- The results indicated that the relationships between S1 amplitude and LVP rising rate are best represented by nonlinear exponential models, challenging previous assumptions of linearity.
Article Abstract
The relationships between the amplitude of the first heart sound (S1) and the rising rate of left ventricular pressure (LVP) concluded in previous studies were not consistent. Some researchers believed the relationship was positively linear; others stated the relationship was only positively correlated. To further investigate this relationship, this study simultaneously sampled the external phonocardiogram, electrocardiogram, and intracardiac pressure in the left ventricle in three anesthetized dogs, while invoking wide hemodynamic changes using various doses of epinephrine. The relationship between the maximum amplitude of S1 and the maximum rising rate of LVP and the relationship between the amplitude of dominant peaks/valleys and the corresponding rising rate of LVP were examined by linear, quadratic, cubic, and exponential models. The results showed that the relationships are best fit by nonlinear exponential models.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835009 | PMC |
| http://dx.doi.org/10.1002/phy2.53 | DOI Listing |
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