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Exploiting the efficient Exo:Cas12i3-5M fusions for robust single and multiplex gene editing in rice.
J Integr Plant Biol
January 2025
State Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences (ICS), Chinese Academy of Agricultural Sciences (CAAS), Beijing, 100081, China.
The development of a single and multiplex gene editing system is highly desirable for either functional genomics or pyramiding beneficial alleles in crop improvement. CRISPR/Cas12i3, which belongs to the Class II Type V-I Cas system, has attracted extensive attention recently due to its smaller protein size and less restricted canonical "TTN" protospacer adjacent motif (PAM). However, due to its relatively lower editing efficiency, Cas12i3-mediated multiplex gene editing has not yet been documented in plants.
View Article and Find Full Text PDFLeadership development programs in healthcare organizations: What they are and how to assemble them.
Health Serv Manage Res
February 2025
LSU Shreveport, Shreveport, LA, USA.
In the highly competitive, perennially-changing healthcare industry, management prowess is vitally needed by those in positions of authority, but in isolation it is insufficient for delivering optimal results. Instead, management proficiencies must be complemented by leadership skills which amplify managerial efforts and outcomes. One avenue for building leadership acumen in healthcare organizations involves the establishment of leadership development programs.
View Article and Find Full Text PDFEvaluating leadership development programs in healthcare organizations: A profile from practice.
Health Serv Manage Res
February 2025
LSU Shreveport, Shreveport, LA, USA.
To enhance leadership acumen and intelligence among the managerial ranks, many healthcare organizations establish leadership development programs. Doing so makes perfect sense as the caliber of leadership within health and medical institutions profoundly influences all aspects of operation. Although leadership development programs are very capable mechanisms for advancing the state of leadership within healthcare organizations, a notable enhancement-evaluation-is needed to maximize their potential.
View Article and Find Full Text PDFA novel artificial intelligence-powered tool for automated root canal segmentation in single-rooted teeth on cone-beam computed tomography.
Int Endod J
January 2025
OMFS IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, University of Leuven, Leuven, Belgium.
Aim: To develop and validate an artificial intelligence (AI)-powered tool based on convolutional neural network (CNN) for automatic segmentation of root canals in single-rooted teeth using cone-beam computed tomography (CBCT).
Methodology: A total of 69 CBCT scans were retrospectively recruited from a hospital database and acquired from two devices with varying protocols. These scans were randomly assigned to the training (n = 31, 88 teeth), validation (n = 8, 15 teeth) and testing (n = 30, 120 teeth) sets.
Prevalence and Etiology of Maxillary Midline Diastema among University Students, Hodeidah Governorate, Yemen: A Cross-sectional Study.
J Contemp Dent Pract
October 2024
Department of Prosthetic Dental Science, College of Dentistry, Jazan University, Jazan, Saudi Arabia, Phone: +00966550599553, e-mail: Orcid: https://orcid.org/0000-0002-9623-261X.
Aim: This study assessed the prevalence and etiological factors of maxillary midline diastema (MMD) in students attending different colleges and universities in Al-Hodeidah governorate, Yemen.
Participants And Methods: A total of 1,661 participants from different universities in Al-Hodeidah governorate were assessed, analyzed, and screened for the presence or absence of MMD. Only 246 had positive MMD and were divided five age-groups.
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