AI Article Synopsis
- The study enhanced glycome profiling in cancer by using a new lectin-assisted fractionation technique.
- Analysis of tissue samples from 45 colorectal cancer patients showed that certain glycoproteins (unfucosylated/α2,6-sialylated) were more prevalent in patients with poorer outcomes.
- This research provides crucial insights that could help in discovering glyco-biomarkers related to cancer.
Article Abstract
To survey the glycome shift in cancer, single-dot tissue glycome profiling was improved by incorporating a lectin-assisted fractionation. The differential analysis of tissue specimens from colorectal cancer patients (n = 45) revealed that unfucosylated/α2,6-sialylated glycoproteins significantly increased in patients with poor prognoses. The detailed annotation will be an indispensable supplement for cancer-related glyco-biomarker discovery.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c3mb70430k | DOI Listing |
Publication Analysis
Top Keywords
single-dot tissue
8
tissue glycome
8
glycome profiling
8
multilectin-assisted fractionation
4
fractionation improved
4
improved single-dot
4
profiling clinical
4
clinical glycoproteomics
4
glycoproteomics survey
4
survey glycome
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!