AI Article Synopsis
- - Vitamin B9, also known as folate, is derived from folic acid and plays a crucial role in various biological processes, particularly in methylation reactions and one-carbon unit transfers.
- - It is vital for converting homocysteine into methionine, a process that relies on vitamin B12, and is involved in synthesizing important biomolecules like purines and pyrimidines.
- - A deficiency in folate can lead to several health issues, such as high levels of homocysteine, megaloblastic anemia, increased risk of cardiovascular disease, neural tube defects in embryos, and potential links to depression and cognitive decline.
Article Abstract
Vitamin B9 is represented by the group of folate, whose structure is derived from folic acid. The biologically active form is reduced tetrahydrofolates, serving as an essential cofactor in methylation reactions, including the vitamin B12-dependent formation of methionine from homocysteine, and as a carrier of one-carbon units involved in the synthesis of purines and pyrimidines. Folate deficiency is associated with hyperhomocysteinemia, megaloblastic anemia, leuco- and thrombocytopenia, cardiovascular disease, embryonic defects, in particular neural tube defects, and, possibly, malignancies, depression and cognitive impairment.
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