AI Article Synopsis
- - Vitamin B1 (thiamine) is essential for energy production from glucose, crucial for the proper functioning of the nervous system.
- - A deficiency in thiamine can lead to serious neurological issues, and doctors measure thiamine status by examining thiamine pyrophosphate levels or transketolase activity in red blood cells.
- - Severe thiamine deficiency is often seen in chronic alcoholics, those with prolonged vomiting during pregnancy, and after bariatric surgery, while mild deficiencies appear common but their effects are not well understood.
Article Abstract
Vitamin B1 (or thiamine) plays a key role in energy production from glucose. Since the main fuel of the nervous system is glucose, thiamine deficiency causes severe neurological symptoms. The biological exploration of vitamin B1 status is based on the measurement of thiamine pyrophosphate concentration or of the activity of a thiamine-dependent enzyme, transketolase, in erythrocytes. Severe deficiency states can be observed in chronic alcoholics, after protracted vomiting during pregnancy and after bariatric surgery. Mild deficiencies are common in the general population, but their clinical consequences are still unclear.
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