Background: Iodine in iodinated contrast agents (ICAs) interferes with radioactive iodine treatment (RAIT) and diagnostic scans in patients with differentiated thyroid carcinoma (DTC) because it can compete with ¹³¹I. Published guidelines recommend delaying RAIT for three to four months in patients who have been exposed to ICA. Spot urinary iodine concentration is a useful marker to reflect the body iodine pool. We investigated the impact of ICAs administered at preoperative computed tomography (CT) scan on the body iodine pool to determine the proper time interval between preoperative CT and RAIT in DTC patients.
Methods: We performed a retrospective review of 1023 patients with DTC who underwent a preoperative CT scan with ICA, total thyroidectomy, and one week of low-iodine diet in preparation for RAIT. Urine iodine excretion (UIE) was measured in spot urine by inductively coupled plasma mass spectrometry and reported both in simple concentration (μg/L) and divided by gram creatinine (μg/gCr). Patients were divided into five groups by time interval in days between preoperative CT scan and spot urine iodine measurement (A, 31-60 [n=29]; B, 61-90 [n=155]; C, 91-120 [n=546]; D, 121-150 [n=226]; E, 151-180 [n=67]).
Results: The median (interquartile range) of UIE (μg/gCr) in each group was 44.4 (27.7-73.2) in group A, 33.3 (22.8-64.7) in group B, 32.7 (20.8-63.0) in group C, 32.0 (20.6-67.0) in group D, and 30.4 (19.6-70.8) in group E. There was no significant difference between group A and the remaining groups (p>0.05) Also, the proportion of patients who achieved the appropriate UIE for RAIT according to our hospital's cutoff (≤66.2 μg/gCr) was not different between groups (A, 72.4%; B, 76.1%; C, 77.5%; D, 74.8%; E, 74.6%) (p=0.78).
Conclusion: This study shows that a UIE of one month after preoperative CT scan with ICA was not higher than that of six months after CT scan in patients who underwent total thyroidectomy for DTC. Thus, current guidelines that recommend delay of RAIT for three to four months after CT scan with ICA should be revisited and future studies to clarify the appropriate time interval between CT scan with ICA and RAIT are warranted.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1089/thy.2013.0238 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Assessment of bystander coronary artery disease in transcatheter aortic valve replacement (TAVR) patients using noncoronary-dedicated planning computed tomography angiography (CTA): diagnostic accuracy in a retrospective real-world cohort.
Clin Radiol
December 2024
Department of Radiology, Division of General Radiology, Medical University of Graz, Auenbruggerplatz 9, 8036 Graz, Austria; Department of Radiology and Nuclear Medicine, University Hospital Wiener Neustadt, Corvinusring 3-5, 2700 Wiener Neustadt, Austria.
Aim: To assess the diagnostic potential of a noncoronary-dedicated pre-TAVR CT angiography (CTA) conducted as a prospective ECG-gated scan without premedication and standard cardiac reconstructions in evaluating bystander coronary artery disease (CAD) against invasive coronary angiography (ICA) as the gold standard.
Materials And Methods: This retrospective study included 232 patients who underwent both CTA and ICA as part of their pre-TAVR evaluation. Exclusion criteria included prior stent, pacemaker, coronary artery bypass, or valve surgery.
Double ophthalmic arteries originating from the internal carotid artery and persistent primitive trigeminal artery.
Surg Radiol Anat
December 2024
Department of Radiology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minamikoshigaya, Koshigaya-shi, Saitama, 343-8555, Japan.
Purpose: Ophthalmic artery (OphA) embryogenesis is a complex process with various origins. We describe herein a case in which the OphA stemmed from the persistent primitive trigeminal artery (PPTA), which has never been reported.
Methods: A man in his 70s was admitted to our hospital following the sudden onset of altered consciousness.
Prognostic Value of Coronary CT Angiography-Derived Quantitative Flow Ratio in Suspected Coronary Artery Disease.
Radiology
December 2024
From the Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China (Z.L., W.Y., L.Q., F.Y.); College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Z.L.); Biomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Med-X Research Institute, 1954 Hua Shan Rd, Room 123, Shanghai 200030, China (Z.L., S.T., G.L., Y.C.); Department of Epidemiology, Johns Hopkins University, Baltimore, Md (M.B.M.); InCor Heart Institute, University of São Paulo Medical School, São Paulo, Brazil (C.E.R., B.R.S.M.); Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (M.Y.C.); German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany (M.D.); and Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (J.M.M., B.R.S.M., J.A.C.L., A.A.Z.).
Background The prognostic value of coronary CT angiography (CTA)-derived quantitative flow ratio (CT-QFR) remains unknown. Purpose To determine the prognostic value of CT-QFR in predicting the long-term outcomes of patients with suspected coronary artery disease (CAD) in comparison with invasive coronary angiography (ICA)/SPECT and to determine the influence of prior percutaneous coronary intervention (PCI) on the prognostic value of CT-QFR. Materials and Methods In this secondary analysis of the prospective international CORE320 study, 379 participants who underwent coronary CTA and SPECT within 60 days before ICA between November 2009 and July 2011 were included for follow-up.
View Article and Find Full Text PDFA US payer budget impact analysis of Flurpiridaz-PET-MPI compared to SPECT-MPI in the diagnosis of coronary artery disease.
J Med Econ
December 2024
GE HealthCare Inc, Marlborough, MA, USA.
Aims: This economic model was developed to assess the budget impact of a novel radiotracer, Flurpiridaz (F-PET-MPI), compared to SPECT-MPI from a US payer perspective.
Materials And Methods: The model was developed comparing F-PET-MPI and SPECT-MPI, with F-PET-MPI modality share increasing from 0.5% to 2.
Can the second phase of contrast-enhanced MRA of the neck provide additional information in the acute stroke setting?
Acta Radiol
December 2024
Department of Radiology, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, India.
Article Synopsis
- - The study explores the effectiveness of a second acquisition during contrast-enhanced MR angiography (CE-MRA) to improve the evaluation of blood flow in patients with past internal carotid artery occlusions.
- - Using a retrospective analysis, researchers compared CE-MRA results with MR perfusion data and digital subtraction angiography (DSA) to assess discrepancies in occlusion locations and collateral blood flow.
- - Findings indicate that 28.5% of patients displayed a false appearance of occlusion in the early phase of CE-MRA, suggesting that the second acquisition could reveal important details missed initially, particularly regarding collateral circulation.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!