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Rescue RM/CS-AKI by blocking strategy with one-dose anti-myoglobin RabMAb.
Nat Commun
January 2025
School of Disaster and Emergency Medicine, Faculty of Medicine, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin, 300072, China.
Rhabdomyolysis or Crush syndrome-related AKI (RM/CS-AKI) has high mortality, and there is no effective early on-site treatment method. The critical pathogenic factor of RM/CS-AKI is the excessive free myoglobin (Mb) in blood circulation. Here, based on the concept of creating a "mobile barrier", we develop an anti-Mb rabbit monoclonal antibody (RabMAb) with high specificity, affinity, stability, and broad species reactivity.
View Article and Find Full Text PDFMultifunctional self-healing and pH-responsive hydrogel dressing based on cationic guar gum and hyaluronic acid for on-demand drug release.
Int J Biol Macromol
January 2025
Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China. Electronic address:
Pathogen invasion and persistent inflammatory storms caused by bacterial infections are the main challenges to the healing of infected wounds. Herein, this study proposed a pH-responsive polysaccharide hydrogel dressing (CG-HA) composed of cationic guar gum (CG) and hyaluronic acid (HA). Additionally, Zn and ferulic acid (FA)/β-cyclodextrin (β-CD) inclusion complexes (FA/β-CD) were co-introduced into the CG-HA hydrogel to form the desired FA/β-CD@CG-HA-Zn hydrogel.
View Article and Find Full Text PDFResonance SERS probe based on the bifunctional molecule IR808 combined with SA test strips for highly sensitive detection of monkeypox virus.
Spectrochim Acta A Mol Biomol Spectrosc
January 2025
Clinical Research Institute, Department of Laboratory Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, College of Chemistry and Chemical Engineering, College of Energy, College of Physical Science and Technology, and Discipline of Intelligent Instrument and Equipment, Xiamen University, Xiamen 361005 China; Scientific Research Foundation of State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Xiamen 361005 China. Electronic address:
As a zoonotic virus, highly sensitive detection of monkeypox virus is crucial for its prevention and control due to its rapid increase in cases worldwide and the extremely high risk of virus transmission. In this paper, based on the principle of antigen-antibody specific recognition, an ultrasensitive resonance Raman biosensing probe was prepared using a molecule with the bifunctionality of resonance Raman effect and capturing antibody; and with the strong affinity of the biotin-streptavidin (Bio-SA) system, Bio-antibody and SA test strips were prepared. To match the T-line of the test strip, a portable Raman instrument with a strip-shaped spot was designed.
View Article and Find Full Text PDFCrystal Structures of Antigen-Binding Fragment of Anti-Osteocalcin Antibody KTM219.
Int J Mol Sci
January 2025
Department of Applied Biology, Faculty of Textile Science and Technology, Shinshu University, Ueda 386-8567, Nagano, Japan.
Osteocalcin is a useful biomarker for bone formation and bone-related diseases. KTM219 is an anti-osteocalcin C-terminal peptide antibody. The single-chain variable region (scFv) and antigen-binding fragment (Fab) of KTM219 are applicable to the Quenchbody (Q-body) immunoassay.
View Article and Find Full Text PDFAnti-Human Leukocyte Antigen Antibody Detection from Terasaki's Humoral Theory to Delisting Strategies in 2024.
Int J Mol Sci
January 2025
Immunology Department, University Hospital Marqués de Valdecilla, 39008 Santander, Spain.
The human leukocyte antigen (HLA) system plays a critical role in transplant immunology, influencing outcomes through various immune-mediated rejection mechanisms. Hyperacute rejection is driven by preformed donor-specific antibodies (DSAs) targeting HLAs, leading to complement activation and graft loss within hours to days. Acute rejection typically occurs within six months post-transplantation, involving cellular and humoral responses, including the formation of de novo DSAs.
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