This manuscript describes the preparation of new small molecule inhibitors of Bacillus anthracis lethal factor. Our starting point was the symmetrical, bis-quinolinyl compound 1 (NSC 12155). Optimization of one half of this molecule led to new LF inhibitors that were desymmetrized to afford more drug-like compounds.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925373 | PMC |
| http://dx.doi.org/10.1016/j.bmc.2013.11.009 | DOI Listing |
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