AI Article Synopsis
- The text describes a new protocol for using palladium to selectively add deuterium to the ortho position of aromatic compounds like phenylacetic and benzoic acids.
- This method provides a catalytic way to produce ortho-deuterated versions of these acids.
- It highlights the differences in how palladacycle intermediates behave based on the strength of their chemical bonds during the reaction.
Article Abstract
We disclose a protocol for the palladium-catalyzed ortho-selective C-H deuteration of arenes. Phenylacetic acids and benzoic acids are suitable substrates for this reaction. This reaction offers a catalytic route to ortho-deuterated phenylacetic acids and benzoic acids and demonstrates the sharp difference in reactivity of palladacycle intermediates held together by weak and strong coordination.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/anie.201305388 | DOI Listing |
Publication Analysis
Top Keywords
palladium-catalyzed ortho-selective
8
ortho-selective c-h
8
c-h deuteration
8
deuteration arenes
8
phenylacetic acids
8
acids benzoic
8
benzoic acids
8
arenes evidence
4
evidence superior
4
superior reactivity
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!