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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930263PMC
http://dx.doi.org/10.1038/eye.2013.251DOI Listing

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From the Ross Eye Institute, University at Buffalo, Buffalo, New York.

Background And Purpose: Retinopathy of prematurity (ROP) is a complex disease. We have established much of the pathophysiology of this disease including the critical roles of retinal metabolic demand and vascular endothelial growth factor (VEGF). The purpose of this paper is to provide some background material and specifically highlight issues that are new, controversial, or underappreciated.

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Many retinal diseases are characterised by changes to retinal vessels. For example, a common condition associated with retinopathy of prematurity (ROP) is so-called plus disease, characterised by increased vascular dilation and tortuosity. This paper presents a general technique for segmenting out vascular structures in retinal images, and characterising the segmented blood vessels.

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