Identification and enzymological study of the multitude of thiamin (vitamin B1)-dependent enzymes open new ways to investigate metabolic regulation and disease treatments. The significant contribution of enzymes employing thiamin diphosphate as a coenzyme to solving medical and biotechnological problems is highlighted, together with the currently underestimated role of the enzymes in controlling the levels of the non-coenzyme thiamin derivatives.
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| http://dx.doi.org/10.1111/febs.12589 | DOI Listing |
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