AI Article Synopsis
- IL-13 is linked to the recruitment of inflammatory cells and regulation of processes relevant to chronic obstructive pulmonary disease (COPD), prompting a study on its plasma levels and gene variations in affected patients.
- A case-control study was conducted involving 160 COPD patients and 175 controls, investigating four specific SNPs in the IL-13 gene to assess their relationship with COPD risk.
- Findings indicated that certain SNPs (rs20541 and rs1800925) in the IL-13 gene were associated with a higher risk of COPD, while plasma IL-13 levels were significantly elevated in COPD patients compared to controls.
Article Abstract
Background: Interleukin-13 (IL-13) has been implicated to be responsible for recruitment of inflammatory cells from the blood to the lung, regulation of matrix metalloproteinase and induction of mucin production and secretion in chronic obstructive pulmonary disease (COPD). We determined plasma IL-13 levels in patients with COPD and investigated its association with common polymorphisms of IL-13 gene in a case-control study.
Methods: We genotyped 160 cases and 175 control subjects in a local hospital using Mass-Array(TM) Technology Platform then tested the association of four SNPs in IL-13 (rs1295685, rs1800925, rs1881457, rs20541) with COPD, and then determined plasma IL-13 levels in patients with COPD and controls.
Results: Association was found between IL-13 gene SNPs (rs20541 and rs1800925) and an increased risk of COPD. By linkage disequilibrium (LD) analysis, two blocks (rs1881457 and rs1800925; rs20541 and rs1295685) were found. The risk of COPD was found associated with the IL-13 gene polymorphism among southern Chinese Han population. Plasma IL-13 level was increased in COPD patients compared with controls.
Conclusions: The polymorphism of the IL-13 gene is associated with an increased risk of COPD in southern Chinese Han population. Plasma IL-13 levels were found elevated in patients with COPD.
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