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| http://dx.doi.org/10.1136/bcr-2013-200743 | DOI Listing |
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Background: Although genetic factors have been identified in the pathogenesis of rheumatoid arthritis (RA), the concordance rate in monozygotic (MZ) twins is low, suggesting that other features contribute to disease development. Further, the relative contribution of such non-genetic elements in identical twins have not been characterized. Here, we aimed to measure differentiating host and microbial biomarkers of RA by studying MZ twins discordant for disease using a multi-omics approach.
View Article and Find Full Text PDFMultiple sclerosis twin study reveals distinct genetic, disease-specific, and psychometric impact on coping with critical life events.
J Neurol Sci
January 2025
Institute of Clinical Neuroimmunology and Biomedical Center (BMC), LMU University Hospital, Faculty of Medicine, LMU Munich, Munich, Germany; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.
Background: Critical life events challenge our competence to develop coping strategies. In people with multiple sclerosis (MS), the impact of genetics, disease-specific, and psychometric factors on coping strategies have not been explored to date.
Methods: In a unique cohort of 56 monozygotic twins discordant for MS, we applied comprehensive psychometric and clinical testing to measure factors influencing the psychosocial impact (including stressors and coping strategies) of a critical life event, exemplified by the COVID-19 pandemic (measured by the COVID-19 Pandemic Mental Health Questionnaire, CoPaQ).
Tribute to Dr Milton Diamond: Twin Studies of Transsexuality/Twin Research Reviews: Loss of a Twin Brother (Recent Memoir); Oxytocin Adminstration During Twin Delivery; Models of Monochorionic Twinning; Twins' Brain Responses to Watching Films/Human Interest: Oldest Conjoined Twins Pass Away; Twins Discordant for Child Abuse; Twins Married to Twins; Rare Quadruplet Set Delivered; Questions of Coincidence; Reared-Apart Twin Valedictorians.
Twin Res Hum Genet
August 2024
Department of Psychology, California State University, Fullerton, California, USA.
A tribute to the life and career of Dr Milton Diamond, a leading figure in twin studies of transsexuality and gender identity, is presented. Dr Diamond is famous for revealing the truth about the unsuccessful effort to change a monozygotic male Canadian twin into a female, following accidental ablation of his penis during circumcision. A short summary of recent twin research on human sexuality and transsexuality, focused on Dr Diamond's contributions, is then presented.
View Article and Find Full Text PDFNegative Life Events and Epigenetic Ageing: A Study in the Netherlands Twin Register.
Behav Genet
December 2024
Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, Netherlands.
We aimed to understand the long-term impact of negative life events on epigenetic aging in 1783 adults from the Netherlands Twin Register, analyzing five epigenetic biomarkers (Hannum, Horvath, PhenoAge, GrimAge, DunedinPACE) and a series of negative life events, including victimization and economic hardship. In population-level analyses, associations between a higher number of negative life events (particularly financial adversities, sexual crimes, and job loss) were seen for the GrimAge biomarker. The association between the number of negative life events and financial problems and epigenetic age acceleration measured by the GrimAge biomarker persisted after adjusting for BMI, smoking, and white blood cell counts.
View Article and Find Full Text PDFEtiology, histology, and long-term outcome of bilateral testicular regression: a large Belgian series.
Hum Reprod Open
December 2023
Department of Internal Medicine and Pediatrics, Ghent University, Pediatric Endocrinology Service, Ghent University Hospital, Belgium, Ghent.
Article Synopsis
- - The study investigates the long-term effects of bilateral testicular regression (BTR) in individuals, focusing on growth and development outcomes, particularly highlighting suboptimal penile growth often related to genetic factors.
- - BTR, a rare condition with potential vascular and genetic origins, was analyzed in a cross-sectional study involving 35 participants recruited from eight pediatric endocrinology departments in Belgium over three years.
- - Key findings revealed common maternal complications during pregnancy and identified specific genetic variants in some participants, while a centralized review of gonadal tissue contributed to understanding the condition's clinical implications.
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