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Effect of deuteration on the metabolism and clearance of some pharmacologically active compounds--synthesis and in vitro metabolism of deuterated derivatives of dronedadrone. | LitMetric
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Effect of deuteration on the metabolism and clearance of some pharmacologically active compounds--synthesis and in vitro metabolism of deuterated derivatives of dronedadrone.

Joseph Schofield Denis Brasseur Béatrice de Bruin Thierry Vassal Sylvie Klieber Catherine Arabeyre Martine Bourrié Freddy Sadoun Gérard Fabre

J Labelled Comp Radiopharm

Isotope Chemistry and Metabolite Synthesis, DSAR-DD, Sanofi R&D, 1 Avenue Pierre Brossolette, 91380, Chilly-Mazarin, France.

Published: August 2014

The synthesis and in vitro metabolism studies of a family of specifically deuterated derivatives of dronedarone are described. Metabolic stability and clearance of the parent compound are not sensitive to deuterium substitution, irrespective of the position of the heavy label.

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http://dx.doi.org/10.1002/jlcr.3090DOI Listing

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