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Secondary congenital nephrotic syndrome complicated by acute mesenteric ischemia: A case report.
Clin Nephrol Case Stud
March 2025
Department of Pediatric Rheumatology and Nephrology, and.
Thromboembolic events are among the most serious, yet rare complications of nephrotic syndrome. While peripheral venous thrombosis and pulmonary embolism are the most common, superior mesenteric artery thrombosis is a rare but life-threatening occurrence. We present a case of severe cytomegalovirus (CMV) infection complicated by congenital nephrotic syndrome, leading to mesenteric ischemia.
View Article and Find Full Text PDFProgression in Fibrotic Interstitial Lung Diseases: Prevalence and Indicators in the Initial Evaluation in a Brazilian Multicentric Cohort.
Cureus
March 2025
Department of Pulmonology, Federal University of São Paulo, São Paulo, BRA.
Objective: This retrospective study aimed to determine the prevalence of progression in fibrotic interstitial lung disease (ILD) and the findings at diagnosis most associated with progression after two years of follow-up in a large Brazilian cohort.
Methods: This was a retrospective multicenter observational study in Brazil. Progression was defined after two years of follow-up.
Preliminary findings of DNA hypermethylation of MDGA1 in idiopathic restless legs syndrome.
Sleep Med
February 2025
Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, PR China. Electronic address:
Background: Both genetic and environmental factors contribute to the development of restless legs syndrome (RLS). Epigenetic mechanisms might play a vital role in RLS but remain underexplored. MDGA1, involved in synaptic inhibition, has been identified by genome-wide association studies as a potential risk gene for RLS.
View Article and Find Full Text PDFEnhanced systemic oxidative stress response in patients with idiopathic inflammatory myopathies.
Arthritis Res Ther
March 2025
Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, Jakubowskiego 2, Kraków, 30-668, Poland.
Background: Idiopathic inflammatory myopathies (IIM) are characterized by chronic inflammation, endothelial dysfunction, and muscle tissue mitochondrial defect, leading to the local oxidative stress response. However, data on its systemic intensity and correlation with IIM clinical and laboratory characteristics remains scarce.
Methods: In clinically stable dermatomyositis (n = 18) and myositis (n = 38) patients and matched controls (n = 50), we measured global oxidative stress response in peripheral blood using a novel coumarin boronic acid (CBA) assay enabling real-time detection of protein hydroperoxides (HP) formed in serum.
Personalized disease recurrence modeling using iPSC-derived podocytes in patients with idiopathic nephrotic syndrome.
Nephrol Dial Transplant
February 2025
Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands.
Background And Hypothesis: Primary focal segmental glomerulosclerosis (FSGS) is characterized by podocyte injury and treatment-resistant nephrotic syndrome. Recurrence of the original disease after kidney transplantation (rFSGS) occurs in 10-50% of patients. Unidentified circulating permeability factors (CPF) are likely involved in FSGS pathogenesis.
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