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Low-Intensity Blast Exposure Induces Multifaceted Long-Lasting Anxiety-Related Behaviors in Mice.
Neurotrauma Rep
December 2024
Truman VA Hospital Research Service, Columbia, Missouri, USA.
Primary blast exposure is a predominant cause of mild traumatic brain injury (mTBI) among veterans and active-duty military personnel, and affected individuals may develop long-lasting behavioral disturbances that interfere with quality of life. Our prior research with the "Missouri Blast" model demonstrated behavioral changes relevant to deficits in cognitive and affective domains after exposure to low-intensity blast (LIB). In this study, behavioral evaluations were extended to 3 months post-LIB injury using multifaceted conventional and advanced behavioral paradigms.
View Article and Find Full Text PDFChanges in serum concentration of perioperative inflammatory cytokines following the timing of surgery among mild-moderate traumatic brain injury patients and factors associated.
Front Neurol
December 2024
Department of Human Repair, Neurosurgery, Ghent University, Ghent, Belgium.
Background: The safe timing window for surgery during the acute phase of inflammation due to traumatic brain injury (TBI) has not been studied extensively. We aimed to elucidate the relationship between the timing of surgery and changes in perioperative serum levels of inflammatory cytokines and factors associated to optimize TBI management in low-middle-income countries.
Methods: A prospective cohort study was conducted among TBI Patients with depressed skull fractures with a GCS > 8 operated at different timing from injury and followed up peri-operatively.
Repeated non-hemorrhagic and non-contusional mild traumatic brain injury in rats elicits behavioral impairment with microglial activation, astrogliosis, and tauopathy: Reproducible and quantitative model of chronic traumatic encephalopathy.
Brain Res
December 2024
Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Chronic traumatic encephalopathy (CTE) has attracted attention due to sports-related head trauma or repetitive mild traumatic brain injury (mTBI). However, the pathology of CTE remains underexplored. Reproducible and quantitative model of CTE has yet to be established.
View Article and Find Full Text PDFEffects of anatomy and head motion on spatial patterns of deformation in the human brain.
Ann Biomed Eng
December 2024
Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, 1 Brookings Drive, MSC 1185-208-125, St. Louis, MO, 63130, USA.
Purpose: To determine how the biomechanical vulnerability of the human brain is affected by features of individual anatomy and loading.
Methods: To identify the features that contribute most to brain vulnerability, we imparted mild harmonic acceleration to the head and measured the resulting brain motion and deformation using magnetic resonance elastography (MRE). Oscillatory motion was imparted to the heads of adult participants using a lateral actuator (n = 24) or occipital actuator (n = 24) at 20 Hz, 30 Hz, and 50 Hz.
Comparative Analysis of Traumatic Brain Injury Severity in Motorcycle and Car Accident Victims Treated at Korle-Bu Teaching Hospital.
J West Afr Coll Surg
August 2024
Neurosurgery Unit, Department of Surgery, Korle-Bu Teaching Hospital, Accra, Ghana.
Background: Traumatic brain injury (TBI) is one of the common causes of long-term disabilities, with about 10 million deaths annually.
Objectives: Our aim is to compare the severity and outcomes of TBI between motorcycle and car accident victims.
Materials And Methods: A prospective cohort study focusing on TBI patients.
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