A dendritic thioester hydrogel based on thiol-thioester exchange as a dissolvable sealant system for wound closure.

Angew Chem Int Ed Engl

Departments of Biomedical Engineering and Chemistry, Boston University, 590 Commonwealth avenue, Boston, MA (USA).

Published: December 2013

A dissolvable dendritic thioester hydrogel based on thiol-thioester exchange for wound closure is reported. The hydrogel sealant adheres strongly to tissues, closes an vein puncture, and withstands high pressures placed on a wound. The hydrogel sealant can be completely washed off upon exposure to thiolates based on thiol-thioester exchange and allow gradual wound re-exposure during definitive surgical care.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000691PMC
http://dx.doi.org/10.1002/anie.201308007DOI Listing

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