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A Landscape of Cancer Initiation and Cancer Stem Cells.
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Laboratory of Cancer Stem Cell Engineering, Faculty of Interdisciplinary Science and Engineering of Health Systems, Okayama University, 3-1-1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan.
Exposure to radiation and chemicals, oncogenic viruses, microbiomes, and inflammation are the major events of cancer initiation. DNA damage and chromosomal aberrations are classically considered the main causes of cancer. The recent idea of epigenetics is broadening the concept, including the suggestion that oncogenic virus infection disrupts various intracellular signaling cascades.
View Article and Find Full Text PDFAberrant Insertion of the Anterior Cruciate Ligament on the Lateral Meniscus: A Case Report.
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January 2025
Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, Connecticut.
Case: A 16-year-old woman presented with acute on chronic knee pain and instability following a twisting injury. The tibial insertion of the anterior cruciate ligament (ACL) was nonvisualized on magnetic resonance imaging. A cord-like ACL, originating from the lateral intercondylar notch and inserting smoothly into the anterior horn of the intact lateral meniscus, was found on arthroscopy.
View Article and Find Full Text PDFElectron Beam-Assisted Au Nanocrystal Shear and Rotation.
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School of Chemical Sciences, University of Auckland, Auckland 1010, New Zealand.
Understanding metastable structural transitions under beam irradiation is essential for the phase engineering of nanomaterials. However, in situ studies of beam-induced structural transitions remain challenging. This work uses an electron beam in aberration-corrected high-angle annular dark-field scanning transmission electron microscopy to irradiate Au nanocrystals at room temperature.
View Article and Find Full Text PDFPedicled Radial Forearm "Free" Flap for Intraoral Reconstruction Based on an Unexpectedly High Origin of the Radial Artery-Case Report.
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Department of Maxillofacial Surgery, University Hospital of Split, 21000 Split, Croatia.
Radial forearm free flap (RFFF) is considered one of the workhorses in modern head and neck reconstruction surgery due to its technical simplicity, versatility and less time-consuming harvest. In this report, we present the case of a 56-year-old woman with sublingual squamous cell carcinoma (SCC) who underwent surgical resection and reconstruction of the defect with a RFFF. The preoperative Allen test showed normal blood flow, and the ultrasound did not recognize any blood vessel abnormalities in the left arm.
View Article and Find Full Text PDFAdenosine deficiency facilitates CA1 synaptic hyperexcitability in the presymptomatic phase of a knockin mouse model of Alzheimer disease.
iScience
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Department of Neuroscience, Tufts University, Boston, MA 02111, USA.
The disease's trajectory of Alzheimer disease (AD) is associated with and negatively correlated to hippocampal hyperexcitability. Here, we show that during the asymptomatic stage in a knockin (KI) mouse model of Alzheimer disease (APP; APPKI), hippocampal hyperactivity occurs at the synaptic compartment, propagates to the soma, and is manifesting at low frequencies of stimulation. We show that this aberrant excitability is associated with a deficient adenosine tone, an inhibitory neuromodulator, driven by reduced levels of CD39/73 enzymes, responsible for the extracellular ATP-to-adenosine conversion.
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