Objective: To study the efficacy of anti-scorpion venom plus prazocin.
Methods: Comparison of clinical features, outcome and duration of stay between children receiving anti-scorpion venom plus prazocin or prazocin alone for management of red scorpion envenomation.
Results: Requirement for dopamine and requirement and duration of dobutamine therapy were significantly less in patients received anti-venom plus prazocin than those had prazocin only. Faster recovery was seen in cases who received anti-scorpion venom plus prazocin than prazocin only group.
Conclusions: Anti-scorpion venom plus prazosin was safe and more effective than prazocin alone for scorpion envenomation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s13312-014-0345-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Development of a gold nanoparticle-based novel diagnostic prototype for detection of Indian red scorpion () venom.
Toxicon X
September 2024
Microbial Biotechnology and Protein Research Laboratory, Department of Molecular Biology and Biotechnology, School of Sciences, Tezpur University, Tezpur, 784028, Assam, India.
Indian red scorpion is responsible for substantial mortality in India and Sri Lanka; however, no specific diagnostic method is available to detect the venom of this scorpion in envenomed plasma or body fluid. Therefore, we have proposed a novel, simple, and rapid method for detecting venom (MTV) in the plasma of envenomed animals using polyclonal antibodies (PAb) raised against three modified custom peptides representing the antigenic epitopes of K (Tamapin) and Na (α-neurotoxin) channel toxins, the two major MTV toxins identified by proteomic analysis. The optimum PAb formulation containing PAb 1, 2, and 3 in proportion (1:1:1, w/w/w) acted synergistically, demonstrating significantly higher immunological recognition of MTV than anti-scorpion antivenom (developed against native toxins) and individual antibodies against peptide immunogens.
View Article and Find Full Text PDFA Novel Therapeutic Formulation for the Improved Treatment of Indian Red Scorpion () Venom-Induced Toxicity-Tested in and Rodent Models.
Toxins (Basel)
August 2023
Microbial Biotechnology and Protein Research Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur 784028, Assam, India.
Indian Red Scorpion () stings are a neglected public health problem in tropical and sub-tropical countries, including India. The drawbacks of conventional therapies using commercial anti-scorpion antivenom (ASA) and α1-adrenoreceptor antagonists (AAA) have prompted us to search for an adequate formulation to improve treatment against stings. Novel therapeutic drug formulations (TDF) of low doses of commercial ASA, AAA, and ascorbic acid have remarkably improved in neutralising the in vivo toxic effects of venom (MTV) tested in and Wistar strain albino rats in vivo models.
View Article and Find Full Text PDFOn the noxious black Amazonian scorpion, Tityus obscurus (Scorpiones, Buthidae): Taxonomic notes, biology, medical importance and envenoming treatment.
Toxicon
June 2023
Pós-Graduação em Biotecnologia e Recursos Naturais da Amazônia, Universidade do Estado do Amazonas (UEA), Manaus, AM, Brazil.
Tityus obscurus has caused mild, moderate and severe accidents of medical relevance in the eastern Brazilian Amazon and French Guiana. Tityus obscurus has sexual dimorphism although males and females have uniform black coloration. In the Amazon, one of the habitats of this scorpion is seasonally flooded forests (igapós and várzeas).
View Article and Find Full Text PDFEthnomedicines for the treatment of scorpion stings: A perspective study.
J Ethnopharmacol
April 2023
Division of Life Sciences, Institute of Advanced Study in Science and Technology, Vigyan Path, Paschim Boragaon, Garchuk, Guwahati, 781035, Assam, India; On Deputation from Tezpur University, Tezpur, Assam, India. Electronic address:
Ethnopharmacological Relevance: Scorpion sting is a public health concern with limited clinical symptomatic treatment. The clinical treatment uses anti-scorpion antivenom and prazosin (α-adrenergic inhibitor), often in combination with insulin, to reduce scorpion venom-induced hyperglycemia and other complications. However, these therapies also possess some limitations, necessitating urgent exploration of ethnomedicines, mainly traditional medicinal plants, to treat scorpion stings.
View Article and Find Full Text PDFIn vitro laboratory analyses of commercial anti-scorpion (Mesobuthus tamulus) antivenoms reveal their quality and safety but the prevalence of a low proportion of venom-specific antibodies.
Toxicon
August 2022
Microbial Biotechnology and Protein Research Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, 784028, Assam, India; Division Of Life Sciences, Institute of Advanced Studies in Science and Technology, Vigyan Path,Garchuk, Paschim Boragaon, Guwahati, 781035, Assam, India. Electronic address:
Mesobuthus tamulus (Indian Red Scorpion) sting is a severe but neglected health issue in India. The accomplishment of in-patient scorpion sting management is highly dependent on the safety, efficacy, and homogeneity of scorpion antivenom preparation. Therefore, in this study, the above qualities of commercial anti-scorpion antivenoms manufactured in India were assessed by in vitro laboratory analyses.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!