The effects of adolescent childbearing and parenting on the academic aptitude and achievement of fourth-grade children were examined by comparing children of mothers in three age groups at the birth of the first child: 15-17 years, 18-19 years, and 20-24 years. The data are from a longitudinal study of a community population of schoolchildren. Outcome measures were tests of cognitive skills at preschool screening, parent and teacher ratings of school performance at grade 3, and tests of aptitude and achievement at grade 4. After controlling for gender, birth order, family structure, and maternal education, results indicated that children of adolescent mothers, whether early or late adolescence, were generally not different from children of mothers in their early 20s with respect to academic ability and performance. Maternal education had a far greater impact on the outcome measures than did maternal age.
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http://dx.doi.org/10.1007/BF02141548 | DOI Listing |
Nat Cancer
January 2025
Department of Hematopoietic Biology and Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Immune checkpoint inhibitors can lead to 'exceptional', durable responses in a subset of persons. However, the molecular basis of exceptional response (ER) to immunotherapy in metastatic clear cell renal cell carcinoma (mccRCC) has not been well characterized. Here we analyzed pretherapy genomic and transcriptomic data in treatment-naive persons with mccRCC treated with standard-of-care immunotherapies: (1) combination of programmed cell death protein and ligand 1 (PD1/PDL1) and cytotoxic T lymphocyte-associated protein 4 inhibitors (IO/IO) or (2) combination of PD1/PDL1 and vascular endothelial growth factor (VEGF) receptor inhibitors (IO/VEGF).
View Article and Find Full Text PDFNat Commun
January 2025
Center for Early Detection and Interception of Blood Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Early therapeutic intervention in high-risk smoldering multiple myeloma (HR-SMM) has shown benefits, however, no studies have assessed whether biochemical progression or response depth predicts long-term outcomes. The single-arm I-PRISM phase II trial (NCT02916771) evaluated ixazomib, lenalidomide, and dexamethasone in 55 patients with HR-SMM. The primary endpoint, median progression-free survival (PFS), was not reached (NR) (95% CI: 57.
View Article and Find Full Text PDFPLoS One
December 2024
Department of Physical Education, College of Education, King Faisal University, Al-Ahsa, Saudi Arabia.
This study investigated the internal and environmental factors contributing to talent development among twice-exceptional elite athletes. Data were gathered through in-depth interviews with athletes diagnosed with a disability who achieved notable sports accomplishments at local, regional, or international levels. The sample included 21 athletes aged 18-56 years.
View Article and Find Full Text PDFBMC Geriatr
December 2024
Institute of Music Physiology and Musicians' Medicine, Hannover University of Music, Drama and Media, Hannover, Germany.
Background: Older adults can acquire new skills across different domains. Practicing a musical instrument has been identified as a promising activity for improving cognition, promoting well-being, and inducing brain plasticity in older individuals. However, the mechanisms of these changes are still poorly understood.
View Article and Find Full Text PDFEur J Sport Sci
January 2025
Department of Sociology and Political Science, Sport Science, Norwegian University of Science and Technology, Trondheim, Norway.
Currently, there is little research on successful talent development environments (TDEs) focusing on women and girls. In response, the main aim of the present study was to compare TDEs of age-specific national teams for girls and boys in the Norwegian context (N = 216: 92 girls and 124 boys). Gender differences were investigated in the two different sports of handball and ice hockey, which in the Norwegian context represent more and less successful sports (handball and ice hockey, respectively).
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