Background: Dermatophytes are the main causative agent of all onychomycosis, but genus Microsporum is infrequent and the risk of acquiring the infection is often associated with exposure to risk factors.
Objectives: To describe clinical characteristics of onychomycosis due to Microsporum onychomycosis in an urban population.
Methods: This was a retrospective analysis of the epidemiological and clinical features of 18 Microsporum onychomycosis cases of a total of 4220 of onychomycosis cases diagnosed between May 2008 and September 2011 at the tertiary referral center for mycology in Guatemala.
Results: Eighteen cases of Microsporum onychomycosis (M. canis, n=10; M. gypseum, n=7; M. nanum, n=1) were identified (prevalence=0.43%). Infection was limited to nails only and disease duration ranged from 1 month to 20 years (mean=6.55 years). The toenails were affected in all cases except for a single M. gypseum case of fingernail. The most common clinical presentation was distal lateral subungual onychomycosis (12/18) followed by total dystrophic onychomycosis (5/18), and superficial white onychomycosis (1/18). M. gypseum presented in 6 cases as distal lateral subungual onychomycosis and in 1 case like total dystrophic onychomycosis. Five cases (27.78%) were associated with hypertension, diabetes, and psoriasis. Treatment with terbinafine or itraconazole was effective. Two cases of M. canis distal lateral subungual onychomycosis responded to photodynamic therapy.
Conclusion: This is the largest reported series of Microsporum onychomycosis and demonstrates such a disease in an urban population. In 27.78% of the cases risk factors for infection were associated to comorbid states. We also report the first 2 cases of successfully treated M. canis onychomycosis with photodynamic therapy and a rare case of M. canis associated dermatophytoma.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9427520 | PMC |
| http://dx.doi.org/10.1016/j.bjid.2013.08.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Nail Lacquer Containing and Essential Oils and Biogenic Silver Nanoparticles for Onychomycosis: Development, Characterization, and Evaluation of Antifungal Efficacy.
Antibiotics (Basel)
September 2024
Laboratory of Innovation and Cosmeceutical Technology, Department of Pharmaceutical Sciences, Center of Health Sciences, Hospital Universitário de Londrina, Robert Koch Avenue, 60, Londrina 86038-350, Brazil.
Article Synopsis
- Onychomycosis, a common fungal nail infection, necessitates new antifungal treatments due to existing resistance and treatment limitations.
- This study developed antifungal nail lacquers using oregano essential oil (OEO), rosemary essential oil (REO), and biogenic silver nanoparticles (bioAgNPs), which showed promising antifungal activity and effective nail permeation.
- Results indicated that these formulations not only reduced fungal hyphae and spores in treated nails but also maintained stability, optimal pH, and quick drying times, marking a significant advancement in treating onychomycosis with natural ingredients and nanotechnology.
Monocentric evaluation of the Novaplex dermatophyte multiplex qPCR assay in the diagnosis of dermatophytoses.
J Clin Microbiol
October 2024
CHU Rennes, Laboratoire de parasitologie-mycologie, European ECMM Excellence Center in Medical Mycology, Centre National de Référence pour les mycoses et antifongiques-Laboratoire associé Aspergilloses chroniques, Rennes, France.
Article Synopsis
- Superficial fungal infections from dermatophytes are common and diagnosing them quickly is important for effective treatment, but traditional methods like fungal culture have drawbacks, including slow results and variable accuracy.
- This study tested the Novaplex dermatophyte assay (a type of real-time PCR) against standard mycological methods using 312 samples and found PCR had a high concordance rate of 87.2% compared to culture methods.
- While the Novaplex assay shows promise with high sensitivity (up to 100% for some targets) and specificity (96.6% for PCR), it cannot fully replace traditional methods since it doesn't detect all mold infections or identify specific dermatophyte species.
Molecular epidemiology and antifungal susceptibility of dermatophytes and Candida isolates in superficial fungal infections at a grade A tertiary hospital in Northern China.
Med Mycol
September 2024
Department of Dermatology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan 030032, China.
Article Synopsis
- * The most common infections reported were onychomycosis, tinea cruris, and tinea corporis, with variations in infection types related to factors like gender, age, and season.
- * Antifungal treatments like terbinafine were highly effective against dermatophytes, while resistance to fluconazole and voriconazole was noted in some Candida strains, highlighting the need for careful antifungal use and ongoing monitoring of resistance patterns. *
Comparative Transcriptome Analysis of T. rubrum, T. mentagrophytes, and M. gypseum Dermatophyte Biofilms in Response to Photodynamic Therapy.
Mycopathologia
June 2024
Dermatology Institute of Fuzhou, Dermatology Hospital of Fuzhou, Xihong Road 243, Fuzhou, 350025, China.
Dermatophyte biofilms frequently count for inadequate responses and resistance to standard antifungal treatments, resulting in refractory chronic onychomycosis infection. Although antimicrobial photodynamic therapy (aPDT) has clinically proven to exert significant antifungal effects or even capable of eradicating dermatophyte biofilms, considerably less is known about the molecular mechanisms underlying aPDT and the potential dysregulation of signaling networks that could antagonize its action. The aim of this study is to elucidate the molecular mechanisms underlining aPDT combat against dermatophyte biofilm in recalcitrant onychomycosis and to decipher the potential detoxification processes elicited by aPDT, facilitating the development of more effective photodynamic interventions.
View Article and Find Full Text PDF[2021 Epidemiological Survey of Dermatomycoses in Japan].
Med Mycol J
December 2023
Department of Dermatology, Saitama Medical University, Saitama Medical Center.
Article Synopsis
- - A 2021 epidemiological survey recorded 9,442 cases of dermatomycoses, predominantly dermatophytosis (86.3%), followed by candidiasis, Malassezia infections, and deep cutaneous mycosis.
- - The most common dermatophytoses included tinea pedis and tinea unguium, with notable increases during summer; a rising trend in cases among patients aged 80 or older was also observed.
- - Trichophyton rubrum and Trichophyton interdigitale were the most frequently isolated fungi, while diaper candidiasis in the elderly emerged as the prevalent type of candidiasis, due to a facility's proactive care strategy.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!