AI Article Synopsis
- A study was conducted to analyze how common dyslipidaemia is among Chinese patients with renal cell carcinoma (RCC), comparing their lipid profiles to 570 matched controls.
- The findings showed that patients with RCC typically had higher levels of low-density lipoprotein (LDL), particularly in advanced cases, with a significant odds ratio indicating a strong association between high LDL levels and RCC.
- The study concluded that elevated LDL was prevalent among RCC patients, but further research in prospective cohorts is needed to confirm these results.
Article Abstract
Objective: To examine the prevalence of dyslipidaemia in patients with renal cell carcinoma (RCC) in a Chinese population.
Patients And Methods: In all, 550 histologically confirmed RCC cases and 570 controls, matched for age and sex were included. Total cholesterol, triglyceride, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) were assessed before treatment using standard techniques. The lipid profiles were defined as 'normal', 'borderline high', 'high' and 'low' according to Chinese Guidelines on Adult Dyslipidaemia. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression in both unadjusted and adjusted models.
Results: Abnormal LDL elevation was common in RCC cases compared with controls (P < 0.001). Results for total cholesterol, triglyceride and HDL levels between groups were insignificant. The OR for RCC for high levels of LDL (≥160 mg/dL) compared with those with a normal LDL profile was 4.675 (95% CI 1.900-11.500). After adjustment for age, gender, body mass index, smoking status, hypertension, diabetes, total cholesterol and triglyceride, the coexistence of high levels of LDL and RCC was large and statistically significant (OR 8.955, 95% CI 3.371-23.786). There was a significant coexistence of RCC for participants with high LDL levels when subgroups of cases with clear cell subtypes and advanced T stages were compared with controls.
Conclusion: Abnormal LDL elevation was prevalent in Chinese patients with RCC. The results remain to be evaluated in prospective cohorts.
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| http://dx.doi.org/10.1111/bju.12581 | DOI Listing |
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