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Targeting Ribosome Biogenesis for Cancer Therapy with Oral Platinum Complexes.
JACS Au
January 2025
School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), State Key Laboratory of Coordination Chemistry, Najing University, Nanjing 210023, PR China.
Cancer cells often upregulate ribosome biogenesis to meet increased protein synthesis demands for rapid proliferation; therefore, targeting ribosome biogenesis has emerged as a promising cancer therapeutic strategy. Herein, we introduce two Pt complexes, ataluren monosubstituted platinum(IV) (SPA, formula: c,c,t,-[Pt(NH)Cl(OH)(CHFNO)], where CHFNO = ataluren) and ataluren bisubstituted platinum(IV) complex (DPA, formula: c,c,t,-[Pt(NH)Cl(CHFNO)], where CHFNO = ataluren), which effectively suppress ribosome biogenesis by inhibiting 47s pre-RNA expression. Furthermore, SPA and DPA induce nucleolar stress by dispersing nucleolar protein NPM1, ultimately inhibiting protein generation in tumor cells.
View Article and Find Full Text PDFResponse mechanism of ethanol-tolerant Saccharomyces cerevisiae strain ES-42 to increased ethanol during continuous ethanol fermentation.
Microb Cell Fact
January 2025
College of Architecture and Environment, Sichuan University, Chengdu, 610065, Sichuan, China.
Background: Continuous fermentation offers advantages in improving production efficiency and reducing costs, making it highly competitive for industrial ethanol production. A key requirement for Saccharomyces cerevisiae strains used in this process is their tolerance to high ethanol concentrations, which enables them to adapt to continuous fermentation conditions. To explore how yeast cells respond to varying levels of ethanol stress during fermentation, a two-month continuous fermentation was conducted.
View Article and Find Full Text PDFAlzheimer's disease may develop from changes in the immune system, cell cycle, and protein processing following alterations in ribosome function.
Sci Rep
January 2025
Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, 474-8511, Aichi, Japan.
The prevalence of Alzheimer's disease (AD) is increasing as society ages. The details of AD pathogenesis have not been fully elucidated, and a comprehensive gene expression analysis of the process leading up to the onset of AD would be helpful for understanding the mechanism. We performed an RNA sequencing analysis on a cohort of 1227 Japanese blood samples, representing 424 AD patients, 543 individuals with mild cognitive impairment (MCI), and 260 cognitively normal (CN) individuals.
View Article and Find Full Text PDFAzurin a potent anticancer and antimicrobial agent isolated from a novel Pseudomonas aeruginosa strain.
Sci Rep
January 2025
Department of Botany and Microbiology, Faculty of Science, Alexandria University, Alexandria, Egypt.
Azurin, a bacterial blue-copper protein, has garnered significant attention as a potential anticancer drug in recent years. Among twenty Pseudomonas aeruginosa isolates, we identified one isolate that demonstrated potent and remarkable azurin synthesis using the VITEK 2 system and 16S rRNA sequencing. The presence of the azurin gene was confirmed in the genomic DNA using specific oligonucleotide primers, and azurin expression was also detected in the synthesized cDNA, which revealed that the azurin expression is active.
View Article and Find Full Text PDFStrategies for processing and valorization of ash gourd byproducts: A comprehensive review.
Food Chem
January 2025
Department of Food Engineering and Technology, Sant Longowal Institute of Engineering and Technology, Longowal 148106, (Sangrur) Punjab, India.
Ash gourd (Benincasa hispida) is cultivated for its medicinal benefits, with processing enhancing its health properties and shelf life. The processing industries generate significant byproducts, with peel and seeds common across all methods, along with lime (from petha sweet production), brine wastewater (from fermented foods), and pulp from juice processing. This review focuses on peel, seeds, and lime wastewater, which contain valuable compounds like polyphenols, terpenoids, essential oils, and ribosome-inactivating proteins known for their antioxidant and antibacterial properties.
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