AI Article Synopsis
- The study examines the variations in breast cancer risk factors across different regions and demographics, highlighting the importance of local characteristics for prevention strategies.
- The research analyzed data from 4,211 women with breast cancer, comparing factors like childbirth, breastfeeding, and weight among different regions, menopausal statuses, and birth periods.
- Key findings indicated that women in more developed regions were less likely to have children and breastfeed, while postmenopausal women showed a stronger association with being overweight and having more childbirths, stressing the need to focus on these risk factors for effective breast cancer risk assessments in Chinese women.
Article Abstract
Background: The characteristics of established risk factors for breast cancer may vary among countries. A better understanding of local characteristics of risk factors may help in devising effective prevention strategies for breast cancer.
Methods: Information on exposures to risk factors was collected from the medical charts of 4211 women with breast cancer diagnosed during 1999-2008. The distributions of these exposures among regions, and by menopausal status and birth period, were compared with the χ(2) test. Crude associations between the selected factors and breast cancer were estimated using the cases in the present study and a representative control population, which was selected from qualified published studies.
Results: As compared with cases from less developed regions, those from more developed regions were significantly more likely to be nulliparous, had fewer childbirths (P < 0.05), and were less likely to have breastfed (P = 0.08). As compared with premenopausal cases, postmenopausal cases were more likely to be overweight and to have breastfed and had more childbirths (P < 0.05). The number of live births and rate of breastfeeding decreased in relation to birth period (P for trends <0.001). Overweight, late menopause, and family history of breast cancer were significantly associated with breast cancer among Chinese women.
Conclusions: Breast cancer incidence was associated with nulliparity and history of breastfeeding. Population attributable risks should be assessed, especially for more developed areas and young women. The effects of body mass index, age at menopause, and family history of breast cancer should be given priority during assessment of breast cancer risk among Chinese women.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872527 | PMC |
| http://dx.doi.org/10.2188/jea.je20120217 | DOI Listing |
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