[Cytogenetic analysis of choroidal melanoma].

Arch Soc Esp Oftalmol

Servicio de Oftalmología, Hospital Universitario de Bellvitge-IDIBELL, Universidad de Barcelona, Hospitalet de Llobregat, Barcelona, España.

Published: January 2014

Purpose: To investigate the presence of known cytogenetic alterations of choroidal melanoma in a series of patients diagnosed and treated in our Ocular Oncology Service. A review of the present literature on this topic is also presented.

Methods: Microsatellite analysis (MSA) studies on loss of heterozygosity (LOH) of chromosome 3, as well as multiplex ligation prove amplification (MLPA) on chromosomes 1, 3, 6 and 8, were performed on enucleation or local resection samples obtained from a total of 27 patients, over a 2 year period.

Results: Twenty patients showed at least one of the cytogenetic alterations looked for. A total of 11 cases were found that showed LOH of chromosome 3 (44%), 8 gains of chromosome 8 (30%), 8 gains of chromosome 6p (30%), and 7 partial or total losses of chromosome 1 (26%).

Conclusions: This is the first study on the cytogenetics of choroidal melanoma performed in our country. The results are similar to that published in the literature. Cytogenetic analysis provides more accurate knowledge on a vital individual prognosis. It also may become a valuable tool for establishing the most adequate follow-up regimes, and the need for adjuvant therapies.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oftal.2013.07.012DOI Listing

Publication Analysis

Top Keywords

cytogenetic alterations
8
choroidal melanoma
8
loh chromosome
8
gains chromosome
8
chromosome 30%
8
chromosome
5
[cytogenetic analysis
4
analysis choroidal
4
choroidal melanoma]
4
melanoma] purpose
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!