AI Article Synopsis
- Remote ischemic preconditioning (RIPC) offers protection against organ damage by inducing temporary ischemia in a distant organ.
- Researchers tested whether microparticles (MPs) extracted from RIPC-exposed rats could reduce damage from strokes in rats with induced cerebral occlusion.
- Results showed that transfusing these MPs decreased the size of the brain injury, but behavioral improvements were not significant, suggesting that while MPs have a protective role, they don’t fully replicate the benefits of RIPC.
Article Abstract
Aim: Remote ischemic preconditioning protects against ischemic organ damage by giving short periods of subcritical ischemia to a remote organ. We tested the hypothesis that remote ischemic conditioning can attenuate cerebral stroke in a rat middle cerebral artery occlusion (MCAO) model by microparticles (MPs).
Methods And Results: MPs were extracted from healthy rats that underwent hindlimb ischemia-reperfusion preconditioning (RIPC), and were transfused into rats that had undergone MCAO without RIPC. The transfusion resulted in an increase in platelet-derived MPs in blood and reduction in infarction area, confirmed by both 2-3-5-triphenyltetrazolium chloride staining and magnetic resonance imaging, albeit to a lesser degree than RIPC itself. Behavioral tests (modified Neurological Severity Score [mNSS]) were calculated to judge the behavioral change. However, no significant difference was observed after MP transfusion in 24 h or the following consecutive 9 days.
Conclusions: RIPC induces an increase in MPs, and platelet-derived MPs may confer at least part of the remote protective effect against cerebral ischemic-reperfusion injury.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493608 | PMC |
| http://dx.doi.org/10.1111/cns.12199 | DOI Listing |
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