AI Article Synopsis
- The study investigates the relationship between estrogen receptor gene variations and body mass index (BMI) in post-menopausal women with high breast density, given the correlation between obesity and increased breast cancer mortality.
- It involved 308 women divided by BMI categories, and analyzed factors like age at menarche, parity, family history of breast cancer, smoking, and alcohol intake.
- Findings suggest that specific mutations in the estrogen receptor can influence BMI, with women having certain genetic markers being more likely to have higher BMI, which, along with other risk factors, increases their risk for breast cancer.
Article Abstract
Objective: Obesity has been associated with increased risk for breast cancer (BC) mortality. Verifying in women with high breast density (HBD) post-menopausal, the frequency of polymorphisms of estrogen receptor (ER)α-PvuII, ERα-XbaI and if they influence the body mass index (BMI).
Methods: Study with 308 women with HBD post-menopause divided into two groups according to BMI: 1st group = BMI < 25 kg/m(2), 2nd group = BMI ≥ 25 kg/m(2). It was characterized in the clinical history: menarche, menopause, parity, family history of BC, smoking and alcohol intake.
Results: Allele and genotype frequencies for the ERα-397-Pvull and ERα-351-XbaI: P = 43.99%, p = 56.01%, pp = 32.14%, Pp = 47.73%, PP = X = 20.13% and X = 41.56%, x = 58.44%; xx = 33.44%; Xx = 50.00%; XX = 16.56%, respectively. Both PvuII and XbaI influenced BMI. When XbaI is mutated the tendency is toward higher BMI (0.039), and women with lower BMI were more frequent in PvuII genotype (p = 0.002). More frequent risk factors for BC: menarche before the age of 12 years (35.38%), nulliparity or 1st child after 28 years old (41.66%), family history of BC (19.16%) and overweight/obesity (62.01%).
Conclusion: Variations in the ERα gene affected the BMI in women with HBD, who already are at increased risk for BC.
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| http://dx.doi.org/10.3109/09513590.2013.859669 | DOI Listing |
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