Dagda et al. showed in this issue that cytosolic PINK1 released from the mitochondrion promotes dendritic outgrowth. This neurite-promoting activity of PINK1 is associated with the kinase activities of protein kinase A and is impaired by a pathogenic mutation in PINK1. The study by Dagda et al. has unravelled a novel mechanism underlying neurodegeneration caused by PINK1 mutation.
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| http://dx.doi.org/10.1111/jnc.12529 | DOI Listing |
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