The article discusses the results of a research on fluorescent diagnostics of skin and mucosal tumors carried out by a workgroup of the Research Institute of Eye Diseases of the Russian Academy of Medical Sciences between 2006 and 2012. The main achievement to be mentioned is the development of an easy to perform, noninvasive, safe and economy method of autofluorescent image acquisition and analysis that does not require the use of protoporphyrin IX precusors or exogenous fluorophores. The research workgroup has also devised an original method of tumor probabilistic border estimation which is valuable for assessment of the extent of surgical intervention. Moreover, a comprehensive approach to evaluation of autofluorescent pattern of the region of interest, that ensures high sensitivity and specificity of diagnostics, has been proposed. Obtained results, in authors' opinion, can likely be extrapolated to neoplasms of other, non-ocular localization.
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