Although there is good clinical evidence suggesting that the psychiatric disorders of epilepsy are clinically distinct, they do not find a place in the current classification systems. To develop a useful classification of the psychopathology of epilepsy, it is important to embrace not only the spectrum of psychiatric diagnoses as given by current psychiatric terminology, as in ICD-10 and DSM-IV, but also those diagnoses related to the classification of seizures and epilepsy. This should be combined with considerable clinical experience in understanding these associations. The Commission on Psychobiology of The International League Against Epilepsy (ILAE) has developed a classification which is shown in this revision. We also describe the bidirectionality between epilepsy and depression and its consequences. A special issue is the overlap between depressive epilepsy-related symptoms and bipolar symptomatology. The psychoses of epilepsy, in the way the ILAE classification considers them, are also reviewed. Finally, we include case reports that illustrate what we understand as the complexity for the clinical diagnosis and therapeutics. Key words.
Download full-text PDF |
Source |
---|
ACS Chem Neurosci
January 2025
Department of Neurology, Ganzhou Hospital-Nanfang Hospital, Southern Medical University, Ganzhou, Jiangxi 341000, China.
Epilepsy is a chronic neurological disorder caused by abnormal discharges of neurons in the brain, which seriously affects the quality of life of patients. Although there are various drug treatments available, many epilepsy patients still experience seizures with the effect of drugs and develop refractory epilepsy. The ketogenic diet can treat drug-refractory epilepsy by regulating the body's metabolism and can enhance the quality of life by improving their cognition, behavior, and sleep quality.
View Article and Find Full Text PDFClin Auton Res
January 2025
Department of Neurology, University Hospital Tulln, Alter Ziegelweg 10, 3430, Tulln, Austria.
Hum Genet
January 2025
Department of Biomedical Sciences, University of Padova, Padova, Italy.
The Genetics of Neurodevelopmental Disorders Lab in Padua provided a new intellectual disability (ID) Panel challenge for computational methods to predict patient phenotypes and their causal variants in the context of the Critical Assessment of the Genome Interpretation, 6th edition (CAGI6). Eight research teams submitted a total of 30 models to predict phenotypes based on the sequences of 74 genes (VCF format) in 415 pediatric patients affected by Neurodevelopmental Disorders (NDDs). NDDs are clinically and genetically heterogeneous conditions, with onset in infant age.
View Article and Find Full Text PDFOrv Hetil
January 2025
1 Szegedi Tudományegyetem, Bölcsészet és Társadalomtudományi Kar, Pszichológia Intézet, Kognitív- és Neuropszichológia Tanszék Szeged, Egyetem u. 2., 6725 Magyarország.
Background: Altered network synchronization and rhythmic neural activity is observed in Alzheimer's disease (AD). Spontaneous epileptiform activity and/or seizures occur in an estimated 60% of AD cases, and having AD increases the likelihood of seizures when compared with people without dementia. Thus, network hyperexcitability can be an early feature and helpful for diagnosis and treatment.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!