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The Pre-Fibroscan and Fibroscan Era: A Comparative Study of Histologic Diagnosis of Liver Biopsies.
West Afr J Med
August 2024
Department of Histopathology, Abubakar Tafawa Balewa University, Bauchi.
Background: The advancement in non-invasive methods for diagnosing and characterizing liver disease has achieved significant success. One such methods, FibroScan, combines non-invasiveness, rapidity, painlessness, and reproducibility. However, its accuracy and value are limited in many clinical settings.
View Article and Find Full Text PDFMedical Assistance in Dying, Slippery Slopes, and Availability of Care: A Reply to Koch.
HEC Forum
December 2024
Northwest Arkansas Community College, Bentonville, AR, 72712, USA.
In 2021, Canada revised its Medical Assistance in Dying (MAID) law, removing the "reasonably foreseeable death" requirement. Opponents of MAID voiced concerns about a "slippery slope" leading to broader access, with some arguing the line has already been crossed. I examine the arguments against expanded eligibility, particularly those presented by Tom Koch (2023).
View Article and Find Full Text PDFRetinal Proteome Profiling of Inherited Retinal Degeneration Across Three Different Mouse Models Suggests Common Drug Targets in Retinitis Pigmentosa.
Mol Cell Proteomics
November 2024
School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland. Electronic address:
Article Synopsis
- Inherited retinal degenerations (IRDs) are a leading cause of blindness in young people, often starting with night vision loss and visual field decline, primarily seen in retinitis pigmentosa (RP).
- The study used different mouse models representing various types of RP and Leber’s congenital amaurosis to analyze retinal proteins, employing consistent methods across institutions for reliable results.
- Findings revealed common issues like inflammation and cellular stress across models, yet distinct pathologies, particularly distinguishing between RP types, while highlighting cAMP and cGMP signaling pathways as potential targets for future therapies.
Perspectives for reproduction and production in grazing sheep and cattle in Australasia: The next 20 years.
Theriogenology
December 2024
Agricultural Systems and Reproduction, Animal Science, Invermay Agricultural Centre, AgResearch Ltd, Puddle Alley, Mosgiel, 9092, New Zealand. Electronic address:
We offer a perspective on the major challenges that are confronting the management of reproduction in sheep and cattle in Australia and New Zealand, over the next two decades. An important context is the dominance of grazing systems in which large flocks or herds are managed over large areas where it is challenging to manage reproduction with precision. Consequently, the variable forage supply usually dominates reproductive outcomes, a problem that will be exacerbated by global heating.
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