Takayasu's arteritis (TA) is an idiopathic vasculitis characterized by granulomatous arteritis of the aorta and its main branches. Here we describe two cases with atypical presentation of TA in Mexican siblings. Both patients had pyoderma gangrenosum and pulmonary nodules throughout the course of their disease. We discuss skin manifestations associated with TA, as well as parenchymal lung involvement, which is unusual in TA and can be related to pyoderma. These cases exemplify the protean manifestations of TA.
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http://dx.doi.org/10.3109/14397595.2013.844384 | DOI Listing |
Rheumatology (Oxford)
March 2025
Vasculitis Unit of Vienna, Vienna, Austria.
The plenary session on clinically relevant outcomes in systemic vasculitis emphasized the significance of monitoring creatinine, haematuria and proteinuria for predicting renal outcomes, recovery of kidney function in severe ANCA glomerulonephritis and outcomes post-kidney transplantation in anti-glomerular basement membrane disease. These findings have the potential to enhance clinical practice by refining prognostication and treatment strategies. Future research gaps include exploring the predictive role of proteinuria and understanding the impact of different clinical phenotypes on disease outcomes in Takayasu arteritis.
View Article and Find Full Text PDFRheumatology (Oxford)
March 2025
Department of General Internal Medicine, UZ Leuven, Leuven, Belgium.
The breakout session "Imaging in Disease Assessment" featured six abstracts on imaging advancements for vasculitis. Disease extent on cranial MRI and its association with visual complications in giant cell arteritis (GCA) was evaluated, introducing the Propensity for Enhancement for GCA (P EG) score to assess inflammation. Predictors of remission and relapse in chronic periaortitis were analyzed, suggesting the potential for tailored treatment approaches.
View Article and Find Full Text PDFArthritis Res Ther
March 2025
Department of Rheumatology and Immunology, Capital Medical University Affiliated Anzhen Hospital, Beijing, China.
Objectives: Takayasu arteritis (TAK) is an inflammatory vasculitis that affects the aorta and its primary branches. The pathogenesis of TAK remains elusive, yet identifying key cell types in the aorta of TAK patients is crucial for uncovering cellular heterogeneity and discovering potential therapeutic targets.
Methods: This study utilized single-cell transcriptome analysis on aortic specimens from three TAK patients, with control data sourced from a publicly available database (GSE155468).
PLoS One
March 2025
Department of Cardiovascular Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Objective: To summarize the existing evidence from double-blind randomized controlled trials (RCTs) and cohort studies regarding the effects of biologic agents for the treatment of large vessel vasculitis (LVV).
Methods: A systematic review and meta-analysis was conducted using MEDLINE, Embase, Cochrane Central Registry of Controlled Trials, and ClinicalTrials.gov covering the period from database inception to May 3rd, 2023.
Arch Rheumatol
December 2024
Department of Internal Medicine, Division of Rheumatology, Marmara University Faculty of Medicine, İstanbul, Türkiye.
Objectives: This study aimed to investigate the expression of proinflammatory cytokines under long-term T helper (Th) 17 cell inducing conditions in Takayasu arteritis (TAK), a granulomatous vasculitis with adaptive immune responses.
Patients And Methods: This cross-sectional study was conducted between May 2014 and April 2017. Peripheral blood mononuclear cells from 25 patients (23 females, 2 males; mean age: 42.
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