An efficient synthesis of olefins by the coupling of stabilized, semistabilized, and nonstabilized phosphorus ylides with various carbonyl compounds in the presence of silver carbonate is reported. Wittig olefination of aromatic, heteroaromatic, and aliphatic aldehydes (yields >63%) and a ketone (yield 42%) are demonstrated. These reactions proceed overnight at room temperature, under weakly basic conditions, and as such extend the applicability of the Wittig reaction to base-sensitive reactants.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894822 | PMC |
| http://dx.doi.org/10.1021/jo401972a | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Therapeutic Potential of Novel Silver Carbonate Nanostructures in Wound Healing and Antibacterial Activity Against and .
Pharmaceuticals (Basel)
November 2024
School of Material Science and Engineering, Tiangong University, Tianjin 300387, China.
: Metallic NPs have been explored for various therapeutic uses owing to utilitarian physicochemical characteristics such as antibacterial, anti-inflammatory, and healing properties. The objective of this study is to evaluate the therapeutic potential of novel silver carbonate nanostructures in promoting wound healing and their antibacterial activity against and . : In this work, we prepared AgCO nanoparticles through a two-step methodology that was expected to improve the material's biomedical performance and biocompatibility.
View Article and Find Full Text PDFEnantioselective Au(I)-Catalyzed Cycloisomerization/Addition of Oxygen Nucleophiles to 2-Alkynylenones by the Tethered Counterion-Directed Catalysis Strategy.
Org Lett
November 2024
Université Paris-Saclay, Centre National de la Recherche Scientifique (CNRS), Institut de Chimie des Substances Naturelles, UPR 2301, 91198 Gif-sur-Yvette, France.
The tethered counterion-directed catalysis (TCDC) strategy enables the Au(I)-catalyzed highly enantioselective synthesis of bicyclic furan derivatives via a reaction sequence combining the cycloisomerization of 2-alkynyl enones and the addition of nucleophiles. A large range of oxygenated nucleophiles, such as water, alcohols, carboxylic acids, and peroxides, have successfully been used as nucleophiles, delivering the chiral furane derivatives in high enantioselectivities (mostly above 90% enantiomeric excess). The CPAphosAuCl complexes were used with catalytic loadings as low as 0.
View Article and Find Full Text PDFCo(III)-catalyzed regioselective benzannulation of substituted pyridones with 1,6-diynes dual C-H bond activation.
Chem Commun (Camb)
August 2024
Department of Chemistry, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India.
A Co(III)-catalyzed site-selective C5 and C6 benzannulation of substituted pyridones with 1,6-diynes dual C-H bond activation has been reported. The scope of the benzannulation reaction was examined with various substituted 2-pyridyl pyridones and 1,6-diynes. The combination of cuprous acetate and silver carbonate plays a crucial role in the success of the reaction.
View Article and Find Full Text PDFEvolution of staining methods in neuroanatomy: Impetus for emanation of neuron doctrine during the turn of 20th century.
Anat Rec (Hoboken)
October 2024
Department of Anatomy, Jagiellonian University Medical College, Krakow, Poland.
The nervous system is distinctive as compared to other tissue systems in human body owing to intricate structural organization. Histological studies played a key role in unveiling complex details of nervous tissue. However, the process of developing suitable staining method for nerve cells was arduous and spanned across almost half a century.
View Article and Find Full Text PDFMultifaceted Assessment of Porous Silica Nanocomposites: Unraveling Physical, Structural, and Biological Transformations Induced by Microwave Field Modification.
Nanomaterials (Basel)
February 2024
Institute of Materials Engineering, University of Silesia, 75 Pulku Piechoty 1A, 41-500 Chorzow, Poland.
Article Synopsis
- Research focuses on using porous silica nanostructures to capture silver and combat environmental contamination from heavy and noble metals.
- The method involves modifying silica surfaces through microwave radiation, enhancing their ability to capture metals and promote the formation of silver nanoparticles with unique properties.
- The study demonstrates that these modified nanocomposites are more effective against microorganisms, highlighting the potential of microwave-modified silicas and nanotechnology in environmental remediation efforts.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!