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Ratio fluorescence and smartphone-assisted colorimetry dual-mode detection of creatinine based on F, B, N-doped of red fluorescent carbon dots.
Anal Chim Acta
May 2025
College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, Guangzhou, 510006, PR China.
Background: Creatinine is a small molecule disease biomarker that reflects kidney function, accurate and effective detection of creatinine will play an important role in the prevention and treatment of diseases. Currently, commonly used creatinine detection methods are limited by expensive instruments, complex sample preparation, many interference factors from biological samples, and environmental factors that can affect the accuracy of the measurement. Therefore, developing a fast, simple, inexpensive, sensitive analysis method that can eliminate background interference and provide multi-detection modes has strong attraction and value.
View Article and Find Full Text PDFLongitudinal association of urinary DHPPA and DHBA with cardiometabolic risk markers in Chinese community-dwelling adults.
Eur J Nutr
March 2025
Department of Nutrition, Center for Big Data and Population Health of IHM, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China.
Purpose: Epidemiological studies using dietary biomarkers to investigate the association between whole grain intake and cardiometabolic health are lacking. We evaluate the 1-year longitudinal associations between urinary alkylresorcinol (AR) metabolites including 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA) and 3,5-dihydroxybenozoic acid (DHBA), biomarkers of whole grain wheat and rye intakes, and cardiometabolic risk markers.
Methods: Total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose, systolic blood pressure (SBP) and diastolic blood pressure (DBP) were repeatedly measured at baseline and after 1-year in 482 Chinese community-dwelling adults.
A Self-Calibrating Chemiluminescence Sensor for Rapid and Precise Antibiotic Prescribing Guidelines on Urinary Tract Infections.
ACS Sens
March 2025
Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Department of Pharmaceutical Analysis, Fujian Medical University, Fuzhou 350004, China.
Traditional antimicrobial-susceptibility testing methodologies, including the isolation and culture of bacteria from urine samples and antibiotic-susceptibility test (AST), are expensive and time-consuming. Therefore, a rapid, user-friendly phenotypic AST is urgently needed to guide treatment strategies. Several novel phenotypic AST platforms based on the physiological characteristics of bacteria obtained directly from clinical urine samples have been proposed as promising methods as rapid AST and appropriate antibiotic treatments.
View Article and Find Full Text PDFA new strategy improving TB diagnosis: stratified urine LAM test based on lymphocyte counts.
Front Cell Infect Microbiol
March 2025
Department of TB Diseases, Affiliated Infectious Diseases Hospital of Zhengzhou University, Zhengzhou, China.
Background: Traditional lipoarabinomannan tests have limited sensitivity in HIV-negative individuals. Our aims were to compare chemiluminescence-based LAM (AIMLAM) and other diagnostic modalities in HIV-negative patients and to explore whether lymphocyte counts impact the sensitivity and costs of AIMLAM.
Methods: This is a prospective, cross-sectional, diagnostic accuracy study.
Label-Free Spectrofluorometric Method for Simultaneous Estimation of Methocarbamol and Aspirin in Biological and Pharmaceutical Matrices: Whiteness and Greenness Evaluation.
Luminescence
March 2025
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
A combination of methocarbamol and aspirin is commonly used for the treatment of acute musculoskeletal pain, such as low back and neck pain. Simultaneous analysis of these analytes in dosage forms and biofluids using rapid, sensitive, and selective methods would be highly beneficial. Herein, we report the first direct, label-free spectrofluorometric method for simultaneously quantifying methocarbamol (MET) and aspirin (ASP) in coformulated tablets and spiked human urine.
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