Background: Kaposi sarcoma-associated herpesvirus (KSHV) is the etiologic agent of primary effusion lymphomas (PEL). PEL cell lines infected with KSHV, but negative for Epstein-Barr virus have a tumorigenic potential in non-obese diabetic/severe combined immunodeficient mice and result in efficient engraftment and formation of malignant ascites with notable abdominal distension, consistent with the clinical manifestations of PEL in humans.
Methodology/principal Findings: Using this preclinical mouse model, we demonstrate that the combination of arsenic trioxide and interferon-alpha (IFN) inhibits proliferation, induces apoptosis and downregulates the latent viral transcripts LANA-1, v-FLIP and v-Cyc in PEL cells derived from malignant ascites. Furthermore, this combination decreases the peritoneal volume and synergistically increases survival of PEL mice.
Conclusion/significance: These results provide a promising rationale for the therapeutic use of arsenic/IFN in PEL patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826709 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079474 | PLOS |
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