AI Article Synopsis
- The research focused on how a new selective COX-2 inhibitor, compound 11b, affects catatonia caused by haloperidol, a medication often used to treat schizophrenia.
- The study found that compound 11b significantly improved catalepsy and enhanced dopamine neurotransmission compared to standard treatment, scopolamine, with results indicating that the effects were dose- and time-dependent.
- These findings suggest that compound 11b could be a promising treatment for catatonia related to schizophrenia and symptoms of rigidity in Parkinson's disease.
Article Abstract
The aim of this research was to investigate the Cyclooxygenase-2 (COX-2) selective inhibition effect on haloperidol-induced catatonia. In this study, the effect of orally, acutely and Sub-chronically administrations of compound 11b [1-(phenyl)-5-(4-methylsulfonylphenyl)-2-ethylthioimidazole] (2, 4 and 8 mg/kg), a newly selective COX-2 inhibitor, was investigated against the haloperidol-induced catatonia phenomenon comparing to the standard drug scopolamine (1 mg/Kg) followed by microdialysis analysis of Striatum dopaminergic neurotransmission. The results showed a great potency for compound 11b in improvement of catalepsy followed by enhancing the dopaminergic neurotransmission p < 0.05. In addition, our statistical analysis showed that the protective effect of compound 11b against haloperidol-induced catatonia was both dose- and time-dependent. These findings are additional pharmacological data that suggest the effectiveness of compound 11b in treatment of schizophrenic drug overdoses and also Parkinson's disease (PD) affiliated rigidity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813089 | PMC |
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