Transient hyperintensity in splenium of corpus callosum is a relatively infrequent finding in MRI. Although it has been most consistently linked with frequent seizure episodes, many other possible causes have been proposed by different workers. Cryptococcal meningitis as a cause of transient splenial hyperintensity has never been reported till date. Here, we report a young girl who is congenitally immunodeficient and had suffered from cryptococcal meningitis with typical transient splenial hyperintense lesions in MRI.
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| http://dx.doi.org/10.4103/0976-3147.118791 | DOI Listing |
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Article Synopsis
- Clinically mild encephalitis/encephalopathy with reversible splenial lesion is marked by temporary neuropsychiatric symptoms and abnormal MRI results showing hyperintensity in the splenium of the corpus callosum.
- A case study revealed postmortem findings of intramyelinic edema and other brain changes in a patient with hypoglycemia and sepsis, suggesting a link between cytotoxic edema and the syndrome.
- Researchers propose that the term "cytotoxic lesions of the corpus callosum" may be relevant for understanding this condition and others with similar causes.
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