AI Article Synopsis
- Asthma is a complex disease with various overlapping types, and researchers are studying biomarkers to help define these types and guide treatment.
- Periostin, a protein linked to TH2-driven asthma, is highlighted as a key biomarker that can indicate airway inflammation and predict how well patients respond to treatments like inhaled corticosteroids and biologic therapies.
- While the initial research on periostin's effectiveness is encouraging, more studies are needed to validate these results and explore additional uses for the biomarker in clinical practice.
Article Abstract
Purpose Of Review: Asthma is a heterogeneous disease with multiple, overlapping phenotypes. Biomarkers are currently being investigated to better characterize the disease phenotypes and to identify the responders to specific targeted therapies. This review focuses on the emerging data surrounding the use of one such biomarker for T helper 2 (TH2)-driven asthma: periostin.
Recent Findings: Periostin is an extracellular matrix protein that is induced by interleukin (IL)-4 and IL-13 in airway epithelial cells and lung fibroblasts. It has proven to be an important biomarker of TH2-associated airway inflammation and a potential predictor of airway eosinophilia. It has also been shown to predict response to treatment with inhaled corticosteroids in patients with these characteristics. Furthermore, recent asthma clinical trials have established that serum periostin may have value in predicting the response to targeted therapy with biologic agents such as lebrikizumab and omalizumab.
Summary: Emerging data suggest a role for periostin in refining asthma phenotypes and predicting the response to targeted therapy. Although early data are promising, further investigations are needed to confirm these findings and to identify other clinical applications in which periostin may be valuable.
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| http://dx.doi.org/10.1097/MCP.0000000000000005 | DOI Listing |
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